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    cmpk2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 570478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cmpk2provided by ZNC
    Official Full Name
    cytidine monophosphate (UMP-CMP) kinase 2, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-24
    See related
    Ensembl:ENSDARG00000031359 AllianceGenome:ZFIN:ZDB-GENE-040724-24
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-276e8.3
    Summary
    Predicted to enable (d)CMP kinase activity; nucleoside diphosphate kinase activity; and thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in mitochondrion. Is expressed in brain; integument; liver; muscle; and pleuroperitoneal region. Orthologous to human CMPK2 (cytidine/uridine monophosphate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cmpk2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (35362882..35375602)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (35414737..35428187)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 144aa Neighboring gene radical S-adenosyl methionine domain containing 2 Neighboring gene SRY-box transcription factor 11a Neighboring gene uncharacterized LOC137488127

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Integration of Metabolomics and Transcriptomics to Reveal the Metabolic Characteristics of Exercise-Improved Bone Mass. Hou JL, et al. Nutrients, 2023 Mar 30. PMID 37049535, Free PMC Article
    2. Identification of fish CMPK2 as an interferon stimulated gene against SVCV infection. Liu W, et al. Fish Shellfish Immunol, 2019 Sep. PMID 31125665
    3. Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Qiu W, et al. Ecotoxicol Environ Saf, 2019 Jun 15. PMID 30826544
    4. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article
    5. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dTDP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UMP-CMP kinase 2, mitochondrial
    XP_699055.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      35362882..35375602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_693963.9 → XP_699055.5  UMP-CMP kinase 2, mitochondrial

      UniProtKB/TrEMBL
      A0A8N7T8K9
      Related
      ENSDARP00000113379.2, ENSDART00000137659.3
      Conserved Domains (2) summary
      COG0125
      Location:221 → 410
      Tmk; Thymidylate kinase [Nucleotide transport and metabolism]
      cl17190
      Location:221 → 409
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein Strain
    Heading Accession and Version

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