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    rasal2 RAS protein activator like 2 [ Danio rerio (zebrafish) ]

    Gene ID: 793730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rasal2provided by ZNC
    Official Full Name
    RAS protein activator like 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-180
    See related
    Ensembl:ENSDARG00000036257 AllianceGenome:ZFIN:ZDB-GENE-070912-180
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc75a03; wu:fc75a03; si:ch211-198i20.2
    Summary
    Predicted to enable GTPase activator activity. Orthologous to human RASAL2 (RAS protein activator like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rasal2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (35732851..35851661)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (35750412..35869204)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 4 Neighboring gene ankyrin repeat domain 45 Neighboring gene DEAH (Asp-Glu-Ala-His) box helicase 9 Neighboring gene laminin, gamma 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein nGAP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      35732851..35851661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001332652.9 → XP_001332688.5  ras GTPase-activating protein nGAP isoform X4

      UniProtKB/TrEMBL
      A0A8M1Q157, F1QX32
      Related
      ENSDARP00000052665.6, ENSDART00000052666.7
      Conserved Domains (6) summary
      cd04013
      Location:330 → 469
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:460 → 790
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:453 → 788
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:780 → 1304
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1176 → 1314
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:204 → 388
      PH-like; Pleckstrin homology-like domain

    2. XM_068214281.1 → XP_068070382.1  ras GTPase-activating protein nGAP isoform X3

    3. XM_005171322.5 → XP_005171379.1  ras GTPase-activating protein nGAP isoform X2

      UniProtKB/TrEMBL
      A0A8M2BIM6
      Conserved Domains (6) summary
      cd04013
      Location:419 → 558
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:549 → 872
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:542 → 870
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:862 → 1386
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1258 → 1396
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:293 → 477
      PH-like; Pleckstrin homology-like domain

    4. XM_005171321.5 → XP_005171378.1  ras GTPase-activating protein nGAP isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIR4
      Conserved Domains (6) summary
      cd04013
      Location:419 → 558
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:549 → 879
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:542 → 877
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:869 → 1393
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1265 → 1403
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:293 → 477
      PH-like; Pleckstrin homology-like domain

    5. XM_005171325.4 → XP_005171382.1  ras GTPase-activating protein nGAP isoform X6

      UniProtKB/TrEMBL
      A0A8M2BIN1
      Conserved Domains (6) summary
      cd04013
      Location:161 → 300
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:291 → 621
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:284 → 619
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:611 → 1135
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1007 → 1145
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:35 → 219
      PH-like; Pleckstrin homology-like domain

    6. XM_005171324.5 → XP_005171381.1  ras GTPase-activating protein nGAP isoform X5

      UniProtKB/TrEMBL
      A0A8M2BJ40
      Conserved Domains (6) summary
      cd04013
      Location:164 → 303
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:294 → 624
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:287 → 622
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:614 → 1138
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:1010 → 1148
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:38 → 222
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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