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    nefma neurofilament medium chain a [ Danio rerio (zebrafish) ]

    Gene ID: 553718, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nefmaprovided by ZNC
    Official Full Name
    neurofilament medium chain aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-205
    See related
    Ensembl:ENSDARG00000021351 AllianceGenome:ZFIN:ZDB-GENE-050522-205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:112359
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in neurofilament bundle assembly. Predicted to be active in axon; cytoplasm; and intermediate filament cytoskeleton. Is expressed in basal plate midbrain region and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See nefma in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (19013850..19018455, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (18977214..18981819, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene MAGUK p55 subfamily member 4-like Neighboring gene uncharacterized LOC137488799 Neighboring gene uncharacterized LOC103909450 Neighboring gene neurofilament light chain a Neighboring gene phosphoglycerate mutase 2 (muscle) Neighboring gene small nucleolar RNA SNORD58 Neighboring gene ribosomal protein L17 Neighboring gene NK6 homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Creation of zebrafish knock-in reporter lines in the nefma gene by Cas9-mediated homologous recombination. Eschstruth A, et al. Genesis, 2020 Jan. PMID 31571409
    2. Tilt in Place Microscopy: a Simple, Low-Cost Solution to Image Neural Responses to Body Rotations. Hamling KR, et al. J Neurosci, 2023 Feb 8. PMID 36517242, Free PMC Article
    3. Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents. Liu Z, et al. Neuron, 2020 Nov 25. PMID 32937099, Free PMC Article
    4. Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b. Marshall-Phelps KLH, et al. J Cell Biol, 2020 Jul 6. PMID 32364583, Free PMC Article
    5. Developmental pattern of the neuronal intermediate filament inaa in the zebrafish retina. Liao ML, et al. J Comp Neurol, 2016 Dec 15. PMID 27159642

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC112359, MGC174282

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neurofilament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intermediate filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic intermediate filament cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neurofilament, medium polypeptide a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111214.2 → NP_001104684.2  neurofilament, medium polypeptide a

      Status: VALIDATED

      Source sequence(s)
      CU467622
      UniProtKB/TrEMBL
      A0A8M1NGQ3, F1QCR7
      Related
      ENSDARP00000074706.5, ENSDART00000080256.6
      Conserved Domains (3) summary
      pfam00038
      Location:83 → 394
      Filament; Intermediate filament protein
      pfam04732
      Location:7 → 80
      Filament_head; Intermediate filament head (DNA binding) region
      pfam15310
      Location:664 → 739
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      19013850..19018455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001020689.1: Suppressed sequence

      Description
      NM_001020689.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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