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    clk4b CDC-like kinase 4b [ Danio rerio (zebrafish) ]

    Gene ID: 503607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clk4bprovided by ZNC
    Official Full Name
    CDC-like kinase 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050227-19
    See related
    Ensembl:ENSDARG00000005908 AllianceGenome:ZFIN:ZDB-GENE-050227-19
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:112975
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Orthologous to human CLK1 (CDC like kinase 1) and CLK4 (CDC like kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See clk4b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (32280904..32301109, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (32247646..32267851, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100333843 Neighboring gene collagen alpha-1(XXIII) chain Neighboring gene collagen alpha-1(XXV) chain-like Neighboring gene si:ch211-247j9.1 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene glutamine-fructose-6-phosphate transaminase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein kinase CLK4b
    NP_001013312.2
    NP_001316837.1
    XP_068071959.1
    XP_068071960.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013294.3 → NP_001013312.2  dual specificity protein kinase CLK4b isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      CR394568, CT646097, EH458583
      UniProtKB/TrEMBL
      A0A2R8QAW9, A0A8M3ALP9
      Related
      ENSDARP00000151729.1, ENSDART00000190676.1
      Conserved Domains (2) summary
      smart00220
      Location:1 → 251
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 251
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001329908.1 → NP_001316837.1  dual specificity protein kinase CLK4b isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CR394568, CT646097, EH432234, EH458583, EH502499
      UniProtKB/TrEMBL
      A0A8M1PAK3, F1QG08
      Related
      ENSDARP00000117099.1, ENSDART00000139890.3
      Conserved Domains (2) summary
      smart00220
      Location:155 → 471
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:142 → 471
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      32280904..32301109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215858.1 → XP_068071959.1  dual specificity protein kinase CLK4b isoform X1

    2. XM_068215859.1 → XP_068071960.1  dual specificity protein kinase CLK4b isoform X2

      UniProtKB/TrEMBL
      A0A2R8QAW9, A0A8M3ALP9
      Related
      ENSDARP00000151722.1, ENSDART00000183050.1
    Nucleotide Protein Strain
    Heading Accession and Version

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