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    arhgap45b Rho GTPase activating protein 45b [ Danio rerio (zebrafish) ]

    Gene ID: 555849, updated on 4-Jan-2025

    Summary

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    Official Symbol
    arhgap45bprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 45bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071213-2
    See related
    Ensembl:ENSDARG00000062049 AllianceGenome:ZFIN:ZDB-GENE-071213-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hmha1; hmha1b; arhgap45; si:ch73-243b8.4
    Summary
    Predicted to enable metal ion binding activity. Predicted to act upstream of or within signal transduction. Orthologous to human ARHGAP45 (Rho GTPase activating protein 45). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See arhgap45b in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (17611836..17652915, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (17586841..17627956, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 4a Neighboring gene RNA polymerase II, I and III subunit E, b Neighboring gene tight junction protein 3 Neighboring gene strawberry notch homolog 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    minor histocompatibility protein HA-1; rho GTPase-activating protein 45
    Names
    Rho GTPase activating protein 45
    histocompatibility (minor) HA-1 b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      17611836..17652915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216452.1 → XP_068072553.1  rho GTPase-activating protein 45 isoform X7

    2. XM_068216451.1 → XP_068072552.1  rho GTPase-activating protein 45 isoform X6

      Related
      ENSDARP00000083604.4, ENSDART00000089171.6

    3. XM_678493.9 → XP_683585.5  rho GTPase-activating protein 45 isoform X5

      UniProtKB/TrEMBL
      A0A8N7USS5
      Conserved Domains (3) summary
      smart00109
      Location:715 → 761
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:773 → 987
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:300 → 544
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_005170516.5 → XP_005170573.1  rho GTPase-activating protein 45 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BI97
      Conserved Domains (3) summary
      smart00109
      Location:724 → 770
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:782 → 996
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:309 → 553
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_005170515.5 → XP_005170572.1  rho GTPase-activating protein 45 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BHU4
      Related
      ENSDARP00000145715.1, ENSDART00000189205.1
      Conserved Domains (3) summary
      smart00109
      Location:724 → 770
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:782 → 996
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:309 → 553
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_005170514.5 → XP_005170571.1  rho GTPase-activating protein 45 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BHV5
      Conserved Domains (3) summary
      smart00109
      Location:724 → 770
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:782 → 996
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:309 → 553
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_005170513.5 → XP_005170570.1  rho GTPase-activating protein 45 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHU6
      Conserved Domains (3) summary
      smart00109
      Location:724 → 770
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:782 → 996
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:309 → 553
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version

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