U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    abca12 ATP-binding cassette, sub-family A (ABC1), member 12 [ Danio rerio (zebrafish) ]

    Gene ID: 558335, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    abca12provided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family A (ABC1), member 12provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9790
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-9790
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb352; sb:cb352; si:dkey-95p16.1
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity; apolipoprotein A-I receptor binding activity; and lipid transporter activity. Acts upstream of or within epidermis morphogenesis. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in EVL; ectoderm; integument; peripheral olfactory organ; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See abca12 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    76
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (40685613..40846467, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (40883825..41044696, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene von Willebrand factor C domain containing 2 like Neighboring gene BRCA1 associated RING domain 1 Neighboring gene uncharacterized LOC137496496 Neighboring gene protein O-fucosyltransferase 2 Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Li Q, et al. Dis Model Mech, 2011 Nov. PMID 21816950, Free PMC Article
    2. Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish. Qiao R, et al. Sci Total Environ, 2019 Sep 10. PMID 31117014
    3. Fate and effects of silver nanoparticles on early life-stage development of zebrafish (Danio rerio) in comparison to silver nitrate. Cambier S, et al. Sci Total Environ, 2018 Jan 1. PMID 28838034
    4. Gene expression profiling in zebrafish embryos exposed to diclofenac, an environmental toxicant. De Felice B, et al. Mol Biol Rep, 2012 Mar. PMID 21643954
    5. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The morphological findings are akin to epidermal changes in harlequin ichthyosis and CEDNIK syndrome, autosomal recessive keratinization disorders due to mutations in the ABCA12 and SNAP29 genes, respectively.
      Title: Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP-binding cassette sub-family A member 12; uncharacterized protein abca12

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      40685613..40846467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_681540.9 → XP_686632.6  uncharacterized protein abca12

      UniProtKB/TrEMBL
      A0A8N7T793
      Conserved Domains (3) summary
      cd03263
      Location:5573 → 5799
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:4666 → 4941
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:4268 → 4588
      ABC2_membrane_3; ABC-2 family transporter protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.