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    marchf7 membrane-associated ring finger (C3HC4) 7 [ Danio rerio (zebrafish) ]

    Gene ID: 100136862, updated on 9-Dec-2024

    Summary

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    Official Symbol
    marchf7provided by ZNC
    Official Full Name
    membrane-associated ring finger (C3HC4) 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-121
    See related
    Ensembl:ENSDARG00000057772 AllianceGenome:ZFIN:ZDB-GENE-080204-121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    axot; march7; zgc:175122
    Summary
    Predicted to enable acid-amino acid ligase activity and zinc ion binding activity. Predicted to be involved in regulation of cell shape and stress fiber assembly. Predicted to be active in plasma membrane. Is expressed in female organism. Orthologous to human MARCHF7 (membrane associated ring-CH-type finger 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See marchf7 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (11781324..11812113, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (11545897..11576686, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene zinc finger, SWIM-type containing 2 Neighboring gene family with sequence similarity 171 member B Neighboring gene uncharacterized LOC137495927 Neighboring gene bromodomain adjacent to zinc finger domain, 2Ba Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. Xiong ST, et al. Int J Biol Macromol, 2023 Jun 15. PMID 37054851
    2. Calcitonin receptor family evolution and fishing for function using in silico promoter analysis. Martins R, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 24815885
    3. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF7
    Names
    axotrophin
    NP_001108052.2
    XP_005165817.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114580.2 → NP_001108052.2  E3 ubiquitin-protein ligase MARCHF7

      See identical proteins and their annotated locations for NP_001108052.2

      Status: VALIDATED

      Source sequence(s)
      AL929243
      UniProtKB/TrEMBL
      A0A8M1NG75, I3IS55
      Related
      ENSDARP00000125719.1, ENSDART00000150989.3
      Conserved Domains (1) summary
      smart00744
      Location:605 → 661
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      11781324..11812113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165760.5 → XP_005165817.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

      See identical proteins and their annotated locations for XP_005165817.1

      UniProtKB/TrEMBL
      A0A8M1NG75, I3IS55
      Conserved Domains (1) summary
      smart00744
      Location:605 → 661
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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