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    xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound [ Danio rerio (zebrafish) ]

    Gene ID: 394007, updated on 4-Jan-2025

    Summary

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    Official Symbol
    xpnpep2provided by ZNC
    Official Full Name
    X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-boundprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1151
    See related
    Ensembl:ENSDARG00000026017 AllianceGenome:ZFIN:ZDB-GENE-040426-1151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zK61O11.1; zgc:63528
    Summary
    Predicted to enable metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See xpnpep2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33591626..33613768, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (33251312..33273454, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 9 Neighboring gene SAM and SH3 domain containing 3 Neighboring gene apelin Neighboring gene vimentin-related 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. Tang V, et al. J Pediatr Gastroenterol Nutr, 2016 Nov. PMID 27526058, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC63528

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    xaa-Pro aminopeptidase 2
    NP_957326.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201032.2 → NP_957326.2  xaa-Pro aminopeptidase 2

      Status: VALIDATED

      Source sequence(s)
      AL929104, BX004980
      UniProtKB/TrEMBL
      A0A8N1Z3N5, Q6ZM25
      Related
      ENSDARP00000025816.6, ENSDART00000010022.9
      Conserved Domains (5) summary
      COG0006
      Location:261 → 628
      PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
      cd01085
      Location:392 → 611
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:79 → 209
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:611 → 675
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:232 → 388
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      33591626..33613768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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