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    usp10 ubiquitin specific peptidase 10 [ Danio rerio (zebrafish) ]

    Gene ID: 564632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp10provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-132
    See related
    Ensembl:ENSDARG00000103422 AllianceGenome:ZFIN:ZDB-GENE-030219-132
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    id:ibd1190; wu:fc19h08; wu:fc76g05; wu:fi11g01
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in DNA damage response, signal transduction by p53 class mediator; regulation of autophagy; and regulation of protein stability. Predicted to act upstream of or within protein deubiquitination and proteolysis. Predicted to be active in cytosol and nucleus. Is expressed in immature eye and optic tectum. Orthologous to human USP10 (ubiquitin specific peptidase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See usp10 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (69146684..69184445, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (68923913..68961751, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene hepatocyte nuclear factor 4-gamma-like Neighboring gene hepatic nuclear factor 4, beta Neighboring gene cysteine-rich secretory protein LCCL domain containing 2 Neighboring gene MARVEL domain containing 3 Neighboring gene PH domain and leucine rich repeat protein phosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    2. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 10
    Names
    ubiquitin specific protease 10
    XP_005169108.1
    XP_005169109.1
    XP_068078884.1
    XP_685621.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      69146684..69184445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222783.1 → XP_068078884.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X4

    2. XM_005169052.5 → XP_005169109.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BGF3
      Related
      ENSDARP00000145430.1, ENSDART00000191359.1
      Conserved Domains (2) summary
      cd02257
      Location:567 → 840
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:460 → 839
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_005169051.5 → XP_005169108.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BGE9
      Conserved Domains (2) summary
      cd02257
      Location:587 → 859
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:480 → 858
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. XM_680529.10 → XP_685621.5  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IVE2, A0A8N7UVN4
      Related
      ENSDARP00000139500.1, ENSDART00000161319.2
      Conserved Domains (2) summary
      cd02257
      Location:587 → 860
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:480 → 859
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein Strain
    Heading Accession and Version

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