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    amt aminomethyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 450000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    amtprovided by ZNC
    Official Full Name
    aminomethyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-114
    See related
    Ensembl:ENSDARG00000010862 AllianceGenome:ZFIN:ZDB-GENE-041010-114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc31f04; wu:fc31f04; wu:fd44b12; wu:fd54h12; zgc:103483; zgc:109741
    Summary
    Predicted to enable aminomethyltransferase activity; methyltransferase activity; and transaminase activity. Predicted to act upstream of or within glycine catabolic process and methylation. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; eye; optic tectum; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See amt in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (26396575..26408839)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (26377436..26389700)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-20d21.12 Neighboring gene hyaluronidase 3 Neighboring gene N-alpha-acetyltransferase 80, NatH catalytic subunit Neighboring gene interferon-related developmental regulator 2 Neighboring gene zgc:136971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. He Z, et al. Biochem Biophys Res Commun, 2019 Sep 10. PMID 31349972, Free PMC Article
    2. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. Ferg M, et al. EMBO J, 2007 Sep 5. PMID 17703193, Free PMC Article
    3. Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Zhu Z, et al. Front Genet, 2020. PMID 32296464, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aminomethyltransferase, mitochondrial
    NP_001006021.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006021.1 → NP_001006021.1  aminomethyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_001006021.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083400
      UniProtKB/TrEMBL
      Q5XJA4
      Related
      ENSDARP00000081585.3, ENSDART00000087151.5
      Conserved Domains (3) summary
      PLN02319
      Location:2 → 407
      PLN02319; aminomethyltransferase
      pfam01571
      Location:46 → 298
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:307 → 399
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      26396575..26408839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394726.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1547..8384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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