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    babam1 BRISC and BRCA1 A complex member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 445296, updated on 9-Dec-2024

    Summary

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    Official Symbol
    babam1provided by ZNC
    Official Full Name
    BRISC and BRCA1 A complex member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040808-6
    See related
    Ensembl:ENSDARG00000077526 AllianceGenome:ZFIN:ZDB-GENE-040808-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nba1; merit40; zgc:100909
    Summary
    Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to act upstream of or within DNA repair; cell division; and chromatin organization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of BRCA1-A complex and BRISC complex. Predicted to be active in nuclear body. Orthologous to human BABAM1 (BRISC and BRCA1 A complex member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See babam1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (6051287..6068412, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (6054032..6071173, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene GTP binding protein 3, mitochondrial Neighboring gene plasmalemma vesicle associated protein b Neighboring gene si:ch73-112j3.1 Neighboring gene U6 spliceosomal RNA Neighboring gene Usher syndrome 1C binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. C9orf72 is essential for neurodevelopment and motility mediated by Cyclin G1. Yeh TH, et al. Exp Neurol, 2018 Jun. PMID 29522758
    2. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Ding Y, et al. Elife, 2022 Oct 18. PMID 36255053, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BRCA1-A complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of BRCA1-A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of BRISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BRISC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of BRISC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    BRISC and BRCA1-A complex member 1
    Names
    BRCA1-A complex subunit MERIT40
    mediator of RAP80 interactions and targeting subunit of 40 kDa
    new component of the BRCA1-A complex

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003752.2 → NP_001003752.2  BRISC and BRCA1-A complex member 1

      Status: VALIDATED

      Source sequence(s)
      BX255969, CN323673, CT573239, EH490619, EH516962
      UniProtKB/Swiss-Prot
      Q6AXK4
      Related
      ENSDARP00000108272.1, ENSDART00000122262.3
      Conserved Domains (1) summary
      TIGR03436
      Location:157 → 208
      acidobact_VWFA; VWFA-related Acidobacterial domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      6051287..6068412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358217.3 → XP_017213706.1  BRISC and BRCA1-A complex member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXK4
      Related
      ENSDARP00000015195.7, ENSDART00000008980.8
      Conserved Domains (1) summary
      TIGR03436
      Location:157 → 208
      acidobact_VWFA; VWFA-related Acidobacterial domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394801.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      245986..246624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXK4.2 GenPept UniProtKB/Swiss-Prot:Q6AXK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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