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    epb41l4a erythrocyte membrane protein band 4.1 like 4A [ Danio rerio (zebrafish) ]

    Gene ID: 30470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epb41l4aprovided by ZNC
    Official Full Name
    erythrocyte membrane protein band 4.1 like 4Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-20
    See related
    Ensembl:ENSDARG00000040087 AllianceGenome:ZFIN:ZDB-GENE-990415-20
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nbl4; EPB41L4; fc29f06; epb4.1l4; wu:fc29f06
    Summary
    Predicted to enable calmodulin binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in cytoplasm. Predicted to be active in cytoskeleton. Orthologous to human EPB41L4A (erythrocyte membrane protein band 4.1 like 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See epb41l4a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (1745260..1827586, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (1717514..1799872, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene linc RNA epb41l4a Neighboring gene galactose-3-O-sulfotransferase 1b Neighboring gene APC regulator of WNT signaling pathway Neighboring gene C3a anaphylatoxin chemotactic receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of human NBL4, a gene involved in the beta-catenin/tcf signaling pathway. Ishiguro H, et al. Jpn J Cancer Res, 2000 Jun. PMID 10874211, Free PMC Article
    2. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SF, et al. BMC Genomics, 2008 Apr 28. PMID 18442396, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 4
    Names
    erythrocyte protein band 4.1-like 4
    protein Nbl4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131223.2 → NP_571298.2  band 4.1-like protein 4

      Status: VALIDATED

      Source sequence(s)
      CABZ01085006, CU459021, EB932300, EH450987, EH476789, EH582231
      UniProtKB/Swiss-Prot
      O57457
      UniProtKB/TrEMBL
      A0A8N7UZH8, E7F2L0
      Related
      ENSDARP00000058626.5, ENSDART00000058627.5
      Conserved Domains (5) summary
      smart00295
      Location:13 → 211
      B41; Band 4.1 homologues
      cd13186
      Location:207 → 296
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:105 → 211
      FERM_M; FERM central domain
      pfam08736
      Location:311 → 354
      FA; FERM adjacent (FA)
      pfam09379
      Location:15 → 82
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      1745260..1827586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479106.2 → XP_021334781.1  band 4.1-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      O57457
      UniProtKB/TrEMBL
      A0A8M9QGE0
      Conserved Domains (3) summary
      smart00295
      Location:13 → 211
      B41; Band 4.1 homologues
      pfam08736
      Location:260 → 303
      FA; FERM adjacent (FA)
      cl17171
      Location:216 → 245
      PH-like; Pleckstrin homology-like domain

    2. XM_068223722.1 → XP_068079823.1  band 4.1-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      O57457
      Related
      ENSDARP00000105721.2, ENSDART00000123842.4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O57457.1 GenPept UniProtKB/Swiss-Prot:O57457

    Gene LinkOut

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