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    hmmr hyaluronan-mediated motility receptor (RHAMM) [ Danio rerio (zebrafish) ]

    Gene ID: 322012, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hmmrprovided by ZNC
    Official Full Name
    hyaluronan-mediated motility receptor (RHAMM)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-731
    See related
    Ensembl:ENSDARG00000021794 AllianceGenome:ZFIN:ZDB-GENE-030131-731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb43e12
    Summary
    Predicted to enable hyaluronic acid binding activity. Acts upstream of or within cardiac muscle tissue regeneration. Predicted to be located in cytoplasm. Is expressed in proliferative region. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human HMMR (hyaluronan mediated motility receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hmmr in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (28545189..28562971)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (28239234..28257013)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene STAG2 cohesin complex component b Neighboring gene zgc:113364 Neighboring gene uncharacterized LOC137487598 Neighboring gene preproinsulin b Neighboring gene uncharacterized LOC137487596

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion. Missinato MA, et al. Dev Dyn, 2021 Jul. PMID 33501711, Free PMC Article
    2. Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Missinato MA, et al. Cardiovasc Res, 2015 Sep 1. PMID 26156497, Free PMC Article
    3. Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. Ouyang X, et al. PLoS One, 2017. PMID 28207787, Free PMC Article
    4. Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Zuppo DA, et al. Development, 2023 Mar 15. PMID 36846912, Free PMC Article
    5. Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. Still IH, et al. BMC Evol Biol, 2004 Jun 18. PMID 15207008, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hmmr are required for activated epicardial cell epithelial-mesenchymal transition
      Title: Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hyaluronan mediated motility receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199580.2 → NP_955874.2  hyaluronan mediated motility receptor

      Status: VALIDATED

      Source sequence(s)
      BX088535
      UniProtKB/TrEMBL
      A0A8M1PD31, E7EYJ3
      Related
      ENSDARP00000104617.4, ENSDART00000125362.5
      Conserved Domains (3) summary
      PRK02224
      Location:333 → 868
      PRK02224; chromosome segregation protein; Provisional
      pfam15905
      Location:16 → 332
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      pfam15908
      Location:744 → 898
      HMMR_C; Hyaluronan mediated motility receptor C-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      28545189..28562971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480967.2 → XP_021336642.1  hyaluronan mediated motility receptor isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZ19
      Related
      ENSDARP00000096680.3, ENSDART00000105902.5
      Conserved Domains (3) summary
      pfam15905
      Location:16 → 333
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      pfam15908
      Location:745 → 899
      HMMR_C; Hyaluronan mediated motility receptor C-terminal
      cl25732
      Location:92 → 869
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394911.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      87841..104279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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