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    fzd2 frizzled class receptor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 30370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fzd2provided by ZNC
    Official Full Name
    frizzled class receptor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-224
    See related
    Ensembl:ENSDARG00000054438 AllianceGenome:ZFIN:ZDB-GENE-990415-224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fz8; zfz2; zg08; cb383; wu:fb70g09
    Summary
    Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within several processes, including Wnt signaling pathway, calcium modulating pathway; heart development; and sensory epithelium regeneration. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; fin; head; head mesenchyme; and mesoderm. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fzd2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (31621824..31624176)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (31490110..31492462)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 43 Neighboring gene minamoto Neighboring gene serine/threonine-protein kinase pim-1-like Neighboring gene myosin, light chain kinase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Establishment of a transitory dorsal-biased window of localized Ca2+ signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos. Ma LH, et al. Dev Biol, 2009 Mar 1. PMID 19133253
    2. Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8. Momoi A, et al. Mech Dev, 2003 Apr. PMID 12676325
    3. Expression of five frizzleds during zebrafish craniofacial development. Sisson BE, et al. Gene Expr Patterns, 2009 Oct. PMID 19595791, Free PMC Article
    4. Inhibition in growth and cardiotoxicity of tris (2-butoxyethyl) phosphate through down-regulating Wnt signaling pathway in early developmental stage of zebrafish (Danio rerio). Xiong H, et al. Ecotoxicol Environ Saf, 2021 Jan 15. PMID 33069947
    5. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Kilian B, et al. Mech Dev, 2003 Apr. PMID 12676324

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. fzd2 are broadly expressed throughout the head, during zebrafish craniofacial development
      Title: Expression of five frizzleds during zebrafish craniofacial development.
    2. conserved role of a Wnt5/Fz2 signaling pathway in islet formation during pancreatic development.
      Title: Wnt5 signaling in vertebrate pancreas development.
    3. frizzled 8c is a receptor for wnt8
      Title: Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway, calcium modulating pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart jogging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within non-canonical Wnt signaling pathway involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory epithelium regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    frizzled-2
    Names
    frizzled homolog 2
    frizzled homolog 8
    fz-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131140.1 → NP_571215.1  frizzled-2 precursor

      See identical proteins and their annotated locations for NP_571215.1

      Status: PROVISIONAL

      Source sequence(s)
      AY033592
      UniProtKB/TrEMBL
      Q90YL7
      Related
      ENSDARP00000071107.3, ENSDART00000076636.5
      Conserved Domains (2) summary
      cd07458
      Location:37 → 154
      CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1
      cd15245
      Location:219 → 548
      7tmF_FZD2; class F frizzled subfamily 2, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      31621824..31624176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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