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    rras RAS related [ Danio rerio (zebrafish) ]

    Gene ID: 449660, updated on 22-Dec-2024

    Summary

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    Official Symbol
    rrasprovided by ZNC
    Official Full Name
    RAS relatedprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-217
    See related
    Ensembl:ENSDARG00000006553 AllianceGenome:ZFIN:ZDB-GENE-041010-217
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb23a02; zgc:92588; wu:fb23a02; wu:fj98h09
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within Notch signaling pathway and maintenance of epithelial cell apical/basal polarity. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in hindbrain and somite. Orthologous to human RRAS (RAS related). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rras in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (32410778..32415974)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (32279064..32284260)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene si:ch211-195b15.8 Neighboring gene proline rich Gla (G-carboxyglutamic acid) 2 Neighboring gene proline rich 12b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Small GTPase R-Ras participates in neural tube formation in zebrafish embryonic spinal cord. Ohata S, et al. Biochem Biophys Res Commun, 2018 Jun 27. PMID 29772239
    2. Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells. Ohata S, et al. Neuron, 2011 Jan 27. PMID 21262462
    3. Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development. Muscò A, et al. Genes (Basel), 2024 Apr 15. PMID 38674426, Free PMC Article
    4. Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Wu Z, et al. Protein Cell, 2023 May 8. PMID 37155312, Free PMC Article
    5. Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Shkumatava A, et al. Genes Dev, 2009 Feb 15. PMID 19240133, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ras related (R-Ras), is a key molecule in the neural tube formation in the developing zebrafish spinal cord.
      Title: Small GTPase R-Ras participates in neural tube formation in zebrafish embryonic spinal cord.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein R-Ras
    Names
    related RAS viral (r-ras) oncogene homolog
    NP_001005931.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005931.2 → NP_001005931.2  ras-related protein R-Ras

      See identical proteins and their annotated locations for NP_001005931.2

      Status: PROVISIONAL

      Source sequence(s)
      BC096943
      UniProtKB/TrEMBL
      A0A2R8RKK0, F6NRS4, Q4V9D8
      Related
      ENSDARP00000014099.8, ENSDART00000025496.10
      Conserved Domains (2) summary
      cd04145
      Location:5 → 168
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
      smart00010
      Location:19 → 170
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      32410778..32415974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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