U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tradd tnfrsf1a-associated via death domain [ Danio rerio (zebrafish) ]

    Gene ID: 58130, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    traddprovided by ZNC
    Official Full Name
    tnfrsf1a-associated via death domainprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000511-5
    See related
    Ensembl:ENSDARG00000036057 AllianceGenome:ZFIN:ZDB-GENE-000511-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zehn0873; wu:fc59e02; zgc:103556; hm:zehn0873
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in cytoplasm; cytoskeleton; and nucleus. Predicted to be part of tumor necrosis factor receptor superfamily complex. Orthologous to human TRADD (TNFRSF1A associated via death domain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tradd in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (29115930..29124578)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (28844780..28853428)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1 Neighboring gene F-box and leucine-rich repeat protein 8 Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b Neighboring gene metallothionein-B-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CRISPR/Cas9-mediated knockout of tnf-α1 in zebrafish reduces disease resistance after Edwardsiella piscicida bacterial infection. Nadarajapillai K, et al. Fish Shellfish Immunol, 2024 Jan. PMID 38040136
    2. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures. Luzio A, et al. Aquat Toxicol, 2016 Aug. PMID 27337697
    3. Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish. Teoh SL, et al. J Chem Neuroanat, 2015 Dec. PMID 26571427
    4. The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis. He BL, et al. PLoS One, 2012. PMID 22615868, Free PMC Article
    5. slc7a6os gene plays a critical role in defined areas of the developing CNS in zebrafish. Benini A, et al. PLoS One, 2015. PMID 25803583, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC103556

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tumor necrosis factor receptor superfamily complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tumor necrosis factor receptor type 1-associated DEATH domain protein
    Names
    TNFR1-associated DEATH domain protein
    TNFRSF1A-associated via death domain protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131607.2 → NP_571682.1  tumor necrosis factor receptor type 1-associated DEATH domain protein

      See identical proteins and their annotated locations for NP_571682.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083425
      UniProtKB/Swiss-Prot
      Q9I9N5
      UniProtKB/TrEMBL
      B2GNQ4
      Related
      ENSDARP00000052344.4, ENSDART00000052345.6
      Conserved Domains (2) summary
      cd08780
      Location:200 → 289
      Death_TRADD; Death Domain of Tumor Necrosis Factor Receptor 1-Associated Death Domain protein
      pfam09034
      Location:59 → 169
      TRADD_N; TRADD, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      29115930..29124578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394694.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      507..9155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I9N5.1 GenPept UniProtKB/Swiss-Prot:Q9I9N5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools