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    daxx death-domain associated protein [ Danio rerio (zebrafish) ]

    Gene ID: 561006, updated on 9-Dec-2024

    Summary

    Official Symbol
    daxxprovided by ZNC
    Official Full Name
    death-domain associated proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010110-3
    See related
    Ensembl:ENSDARG00000000729 AllianceGenome:ZFIN:ZDB-GENE-010110-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fd15c03; si:dz179b20.7
    Summary
    Enables transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See daxx in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7014451..7033667, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7095790..7114740, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene kinesin family member C1 Neighboring gene zinc finger and BTB domain containing 22b Neighboring gene TAP binding protein (tapasin), tandem duplicate 1 Neighboring gene major histocompatibility complex class I UKA

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in PML body  
    located_in chromosome  
    located_in chromosome, centromeric region  
    located_in cytoplasm  
    located_in nucleolus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    death domain-associated protein 6
    Names
    death-associated protein 6
    fas-binding

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044949.1 → NP_001038414.1  death domain-associated protein 6

      See identical proteins and their annotated locations for NP_001038414.1

      Status: PROVISIONAL

      Source sequence(s)
      BX927188
      UniProtKB/TrEMBL
      A0A8M2B6B4, Q1LUU4
      Related
      ENSDARP00000105452.1, ENSDART00000123443.3
      Conserved Domains (2) summary
      cd13150
      Location:195 → 400
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:53 → 151
      Daxx; Daxx N-terminal Rassf1C-interacting domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      7014451..7033667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352251.3 → XP_017207740.1  death domain-associated protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YWD7
    2. XM_005159438.5 → XP_005159495.2  death domain-associated protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6F2
      Conserved Domains (2) summary
      cd13150
      Location:242 → 447
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:100 → 198
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    3. XM_068215153.1 → XP_068071254.1  death domain-associated protein 6 isoform X4

      Related
      ENSDARP00000108588.2, ENSDART00000122815.4
    4. XM_005159440.5 → XP_005159497.1  death domain-associated protein 6 isoform X3

      See identical proteins and their annotated locations for XP_005159497.1

      UniProtKB/TrEMBL
      A0A8M2B6B4, Q1LUU4
      Conserved Domains (2) summary
      cd13150
      Location:195 → 400
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:53 → 151
      Daxx; Daxx N-terminal Rassf1C-interacting domain
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