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    celf2 cugbp, Elav-like family member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 373117, updated on 9-Dec-2024

    Summary

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    Official Symbol
    celf2provided by ZNC
    Official Full Name
    cugbp, Elav-like family member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-35
    See related
    Ensembl:ENSDARG00000002131 AllianceGenome:ZFIN:ZDB-GENE-030826-35
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Etr-3; cb906; cugbp2; fj87b07; wu:fj87b07
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adaxial cell; immature eye; musculature system; nervous system; and neural plate. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF2 (CUGBP Elav-like family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See celf2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (23886136..24161931, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (24160620..24396077, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene USP6 N-terminal like Neighboring gene carboxypeptidase M Neighboring gene uncharacterized LOC137491551 Neighboring gene uncharacterized LOC137491399

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of alternative splicing of alpha-actinin transcript by Bruno-like proteins. Suzuki H, et al. Genes Cells, 2002 Feb. PMID 11895477
    2. Isolation and expression of Napor/CUG-BP2 in embryo development. Choi DK, et al. Biochem Biophys Res Commun, 2003 Jun 6. PMID 12763013
    3. Conserved functions of RNA-binding proteins in muscle. Nikonova E, et al. Int J Biochem Cell Biol, 2019 May. PMID 30818081
    4. Triclosan regulates alternative splicing events of nerve-related genes through RNA-binding protein CELF2 to induce zebrafish neurotoxicity. Wang D, et al. J Hazard Mater, 2021 Jul 5. PMID 33621777
    5. Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Ghosh P, et al. Neural Dev, 2018 Jun 26. PMID 29945667, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cloning and expression of Napor/CUG-BP2 in embryo development.
      Title: Isolation and expression of Napor/CUG-BP2 in embryo development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUGBP Elav-like family member 2
    Names
    CELF-2
    CUG triplet repeat RNA-binding protein 2
    CUG-BP- and ETR-3-like factor 2
    CUG-BP2
    ELAV-type RNA-binding protein 3
    RNA-binding protein BRUNOL-3
    bruno-like protein 3
    napor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194401.1 → NP_919382.1  CUGBP Elav-like family member 2

      See identical proteins and their annotated locations for NP_919382.1

      Status: PROVISIONAL

      Source sequence(s)
      AB050496
      UniProtKB/Swiss-Prot
      Q4U0V4, Q4U0V6, Q6P0B1, Q8QGX2, Q90ZV0
      Related
      ENSDARP00000122415.1, ENSDART00000132615.3
      Conserved Domains (4) summary
      cd12631
      Location:15 → 98
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:107 → 187
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:394 → 485
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      TIGR01661
      Location:18 → 481
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      23886136..24161931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219542.1 → XP_068075643.1  CUGBP Elav-like family member 2 isoform X13

      UniProtKB/TrEMBL
      A0A8M9Q087

    2. XM_017354958.3 → XP_017210447.1  CUGBP Elav-like family member 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z5W1, A0A8M9Q087
      Conserved Domains (3) summary
      cd12631
      Location:51 → 134
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:143 → 223
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:456 → 547
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    3. XM_068219540.1 → XP_068075641.1  CUGBP Elav-like family member 2 isoform X11

      UniProtKB/Swiss-Prot
      Q4U0V4, Q4U0V6, Q6P0B1, Q8QGX2, Q90ZV0

    4. XM_068219539.1 → XP_068075640.1  CUGBP Elav-like family member 2 isoform X10

      UniProtKB/Swiss-Prot
      Q4U0V4, Q4U0V6, Q6P0B1, Q8QGX2, Q90ZV0

    5. XM_068219548.1 → XP_068075649.1  CUGBP Elav-like family member 2 isoform X19

      UniProtKB/TrEMBL
      A0A8M9Q0A2

    6. XM_068219545.1 → XP_068075646.1  CUGBP Elav-like family member 2 isoform X16

      UniProtKB/TrEMBL
      A0A8M9Q097

    7. XM_068219547.1 → XP_068075648.1  CUGBP Elav-like family member 2 isoform X18

      UniProtKB/TrEMBL
      A0A8M9PU91

    8. XM_068219544.1 → XP_068075645.1  CUGBP Elav-like family member 2 isoform X15

      UniProtKB/TrEMBL
      A0A8M9PU86

    9. XM_068219537.1 → XP_068075638.1  CUGBP Elav-like family member 2 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PU80

    10. XM_068219533.1 → XP_068075634.1  CUGBP Elav-like family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q087

    11. XM_068219536.1 → XP_068075637.1  CUGBP Elav-like family member 2 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PH20

    12. XM_068219534.1 → XP_068075635.1  CUGBP Elav-like family member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QB04

    13. XM_068219535.1 → XP_068075636.1  CUGBP Elav-like family member 2 isoform X4

      UniProtKB/Swiss-Prot
      Q4U0V4, Q4U0V6, Q6P0B1, Q8QGX2, Q90ZV0

    14. XM_068219532.1 → XP_068075633.1  CUGBP Elav-like family member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PH27, A0A8M9Q087

    15. XM_068219538.1 → XP_068075639.1  CUGBP Elav-like family member 2 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PH30, A0A8M9Q087

    16. XM_068219555.1 → XP_068075656.1  CUGBP Elav-like family member 2 isoform X29

      UniProtKB/TrEMBL
      A0A8M9QB19

    17. XM_068219554.1 → XP_068075655.1  CUGBP Elav-like family member 2 isoform X27

      UniProtKB/TrEMBL
      A0A8M9Q5T3

    18. XM_021474959.2 → XP_021330634.1  CUGBP Elav-like family member 2 isoform X9

      UniProtKB/TrEMBL
      A0A8M9PU94, A0A8M9Q5T3
      Conserved Domains (3) summary
      cd12631
      Location:51 → 134
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:143 → 223
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:385 → 476
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    19. XM_068219553.1 → XP_068075654.1  CUGBP Elav-like family member 2 isoform X26

      UniProtKB/TrEMBL
      A0A8M9QB19

    20. XM_068219552.1 → XP_068075653.1  CUGBP Elav-like family member 2 isoform X24

      UniProtKB/Swiss-Prot
      Q4U0V4, Q4U0V6, Q6P0B1, Q8QGX2, Q90ZV0

    21. XM_068219550.1 → XP_068075651.1  CUGBP Elav-like family member 2 isoform X22

      UniProtKB/TrEMBL
      A0A8M9Q5T3

    22. XM_005164862.5 → XP_005164919.1  CUGBP Elav-like family member 2 isoform X25

      See identical proteins and their annotated locations for XP_005164919.1

      UniProtKB/TrEMBL
      A0A8M9PH35, A0A8M9QB19
      Related
      ENSDARP00000025183.9, ENSDART00000017443.9
      Conserved Domains (3) summary
      cd12631
      Location:61 → 144
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:153 → 233
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:391 → 482
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    23. XM_068219551.1 → XP_068075652.1  CUGBP Elav-like family member 2 isoform X23

      UniProtKB/Swiss-Prot
      Q4U0V4, Q4U0V6, Q6P0B1, Q8QGX2, Q90ZV0

    24. XM_068219549.1 → XP_068075650.1  CUGBP Elav-like family member 2 isoform X21

      UniProtKB/TrEMBL
      A0A8M9QB19

    25. XM_068219543.1 → XP_068075644.1  CUGBP Elav-like family member 2 isoform X14

      UniProtKB/Swiss-Prot
      Q4U0V4, Q4U0V6, Q6P0B1, Q8QGX2, Q90ZV0

    26. XM_068219541.1 → XP_068075642.1  CUGBP Elav-like family member 2 isoform X12

      UniProtKB/Swiss-Prot
      Q4U0V4, Q4U0V6, Q6P0B1, Q8QGX2, Q90ZV0
      UniProtKB/TrEMBL
      A0A8M9QB24
      Related
      ENSDARP00000112156.2, ENSDART00000128368.3

    27. XM_068219546.1 → XP_068075647.1  CUGBP Elav-like family member 2 isoform X17

      UniProtKB/TrEMBL
      A0A8M9Q5T1

    28. XM_005164864.5 → XP_005164921.1  CUGBP Elav-like family member 2 isoform X28

      See identical proteins and their annotated locations for XP_005164921.1

      UniProtKB/TrEMBL
      A0A8M9PU99, A0A8M9Q5T3
      Conserved Domains (3) summary
      cd12631
      Location:47 → 130
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:139 → 219
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:381 → 472
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    29. XM_005164860.5 → XP_005164917.1  CUGBP Elav-like family member 2 isoform X20

      See identical proteins and their annotated locations for XP_005164917.1

      UniProtKB/TrEMBL
      A0A8M2BC67, A0A8M9QB14, Q4U0V5
      Related
      ENSDARP00000072392.4, ENSDART00000077926.6
      Conserved Domains (3) summary
      cd12631
      Location:47 → 130
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:139 → 219
      RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12638
      Location:401 → 492
      RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395232.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      243510..318780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P0B1.1 GenPept UniProtKB/Swiss-Prot:Q6P0B1

    Gene LinkOut

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