flot1a flotillin 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: flot1aprovided by ZNC
Official Full Name: flotillin 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020430-1
See related: Ensembl:ENSDARG00000001710 AllianceGenome:ZFIN:ZDB-GENE-020430-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: flot1; reggie2; wu:fj45g11; si:dz44o19.1
Summary: Predicted to enable protease binding activity. Predicted to be involved in several processes, including positive regulation of cell-cell adhesion mediated by cadherin; protein kinase C signaling; and regulation of endocytosis. Predicted to be located in endosome and membrane. Predicted to be part of flotillin complex. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human FLOT1 (flotillin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (6938248..6957405)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (7019345..7038476)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results provide the first in vivo evidence that Flotillins regulate E-cadherin-mediated cell-cell junctions to allow epiboly progression.
Title: Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion.
Analysis of reggie mRNA and protein expression patterns during early zebrafish development revealed that re-1a mRNA is present at high levels in expression domains that overlap with the combined expression pattern of both re-2 genes except at the somites.
Title: Restricted expression of reggie genes and proteins during early zebrafish development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein kinase C signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
part_of flotillin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: flotillin-1a

Names: flotillin 1; reggie-2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130913.1 → NP_570988.1 flotillin-1a

See identical proteins and their annotated locations for NP_570988.1

Status: PROVISIONAL

Source sequence(s)

BX927188

UniProtKB/TrEMBL

A0A286Y8S9, A0A8N7XJ54, Q1LUU9, Q7ZZ76

Related

ENSDARP00000143360.2, ENSDART00000178832.2

Conserved Domains (4) summary

COG2268
Location:4 → 425

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:30 → 175

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam15975
Location:308 → 385

Flot; Flotillin

cl19107
Location:241 → 337

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

6938248..6957405

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159441.5 → XP_005159498.1 flotillin-1a isoform X1

UniProtKB/TrEMBL

A0A8M2B653, F1QEW4

Related

ENSDARP00000123148.2, ENSDART00000139122.4

Conserved Domains (4) summary

smart00244
Location:84 → 255

PHB; prohibitin homologues

cd03399
Location:30 → 175

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam15975
Location:308 → 385

Flot; Flotillin

cl19107
Location:241 → 337

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily