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    tyms thymidylate synthetase [ Danio rerio (zebrafish) ]

    Gene ID: 81540, updated on 9-Dec-2024

    Summary

    Official Symbol
    tymsprovided by ZNC
    Official Full Name
    thymidylate synthetaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-59
    See related
    Ensembl:ENSDARG00000042894 AllianceGenome:ZFIN:ZDB-GENE-040426-59
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56465; zgc:77659
    Summary
    Enables thymidylate synthase activity. Acts upstream of or within dTMP biosynthetic process and retina development in camera-type eye. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including anterior neural tube; blood; nervous system; optic vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cerebral infarction; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See tyms in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71535053..71541333)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71293912..71300192)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene alkaline ceramidase 2 Neighboring gene adenylate cyclase activating polypeptide 1a Neighboring gene methyltransferase 4, N6-adenosine

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 5,10-methylenetetrahydrofolate-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thymidylate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thymidylate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thymidylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity, transferring one-carbon groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dTMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within dTMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dTTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    thymidylate synthase
    NP_571835.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131760.2NP_571835.2  thymidylate synthase

      Status: VALIDATED

      Source sequence(s)
      EH577904, EH580067, FP016237
      UniProtKB/TrEMBL
      A0A8M1P903, Q6P045
      Related
      ENSDARP00000047068.6, ENSDART00000047069.7
      Conserved Domains (1) summary
      pfam00303
      Location:38318
      Thymidylat_synt; Thymidylate synthase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      71535053..71541333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)