cat catalase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: catprovided by ZNC
Official Full Name: catalaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000210-20
See related: Ensembl:ENSDARG00000104702 AllianceGenome:ZFIN:ZDB-GENE-000210-20
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb68a12; wu:fb68a12
Summary: Predicted to enable catalase activity and heme binding activity. Acts upstream of or within response to copper ion. Predicted to be located in peroxisomal matrix. Predicted to be active in mitochondrion and peroxisome. Is expressed in several structures, including digestive system; eye; gill; muscle; and ventricular zone. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (7492757..7502419)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (7318717..7328379)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impact of benzophenone-3 on the integument and gills of zebrafish (Danio rerio).
Title: Impact of benzophenone-3 on the integument and gills of zebrafish (Danio rerio).
fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1.
Title: Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.
Antioxidants diphenyliodonium and N-acetylcysteine or overexpression of zebrafish catalase in GF-1 cells also reduced ROS production and protected cells for enhancing host survival rate due to red-spotted grouper nervous necrosis virus infection.
Title: Betanodavirus induces oxidative stress-mediated cell death that prevented by anti-oxidants and zfcatalase in fish cells.
Treatment of light responsive cells with hydrogen peroxide triggers induction of this gene.
Title: Circadian control by the reduction/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catalase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to copper ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hydrogen peroxide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catalase

NP_570987.2

EC 1.11.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.