oaz1a ornithine decarboxylase antizyme 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: oaz1aprovided by ZNC
Official Full Name: ornithine decarboxylase antizyme 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020731-4
See related: Ensembl:ENSDARG00000071403 AllianceGenome:ZFIN:ZDB-GENE-020731-4
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: AZS; oaz1
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. Several antizyme paralogs have been described in zebrafish. The mRNA for this antizyme is ubiquitously expressed in the embryo and differentially expressed during development from embryo to adult fish. This antizyme shares features in common with mammalian antizyme 1: it negatively regulates intracellular polyamine levels by inhibiting ODC activity and accelerating ODC degradation in vitro; like mammalian antizyme 1 mRNA, this antizyme mRNA contains two potential in-frame translation initiation sites. [provided by RefSeq, Jan 2015]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (20714624..20720445, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (20689646..20695467, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj13h08.x1 (e-PCR)
- UniSTS:198584

oaz (e-PCR)
- UniSTS:205554

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ornithine decarboxylase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ornithine decarboxylase antizyme 1a

Names: ODC antizyme; ODC-Az-S; ornithine decarboxylase antizyme 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.