pdgfra platelet-derived growth factor receptor, alpha polypeptide [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdgfraprovided by ZNC
Official Full Name: platelet-derived growth factor receptor, alpha polypeptideprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-208
See related: Ensembl:ENSDARG00000070494 AllianceGenome:ZFIN:ZDB-GENE-990415-208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pdgfr-a; wu:fc27f02; wu:fv91b12; etID309717.20
Summary: Predicted to enable platelet-derived growth factor alpha-receptor activity and platelet-derived growth factor binding activity. Acts upstream of or within several processes, including circulatory system development; embryonic neurocranium morphogenesis; and neural crest cell migration. Predicted to be located in Golgi apparatus and cilium. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; head; mesoderm; nervous system; and neural crest. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypereosinophilic syndrome; and pancreatic cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (22435179..22476263, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (22536703..22564571, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafish pdgfra mutants, suggesting that PDGF signaling steers cardiomyocytes toward the midline during cardiac fusion. Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra-expressing myocardial precursors.
Title: Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly.
Pdgf/Pdgfr signalling guides neural crest contribution to the haematopoietic stem cell specification niche.
Title: Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche.
Untreated pdgfra mutants have cleft palate due to defective neural crest cell migration, whereas pdgfra heterozygotes develop normally.
Title: Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD.
pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation
Title: Platelet-derived growth factor receptor alpha (pdgfr-alpha) gene in zebrafish embryonic development.
Protean differentiation and proliferation pathways are commonly regulated by PDGFRa, PDGFRb and PDGFRa/b while each receptor is also responsible for regulating unique signaling pathways. Some signaling is solely modulated through heterodimeric PDGFRa/b.
Title: Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.
The conserved regulatory interactions of mirn140 and pdgfra define an ancient mechanism of palatogenesis, and they provide candidate genes for cleft palate.
Title: MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis.

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General gene information

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Markers

fc27f02.x1 (e-PCR)
- UniSTS:193364

Z32814 (e-PCR)
- UniSTS:205422

fc27f02.x1 (e-PCR)
- UniSTS:187883

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle progenitor cell migration to the midline involved in heart field formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardioblast cell midline fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellum vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in embryonic cranial skeleton morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic neurocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic neurocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: platelet-derived growth factor receptor alpha

Names: PDGF-R-alpha; PDGFR-alpha; alpha-type platelet-derived growth factor receptor

NP_571534.2

EC 2.7.10.1

XP_068071492.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131459.3 → NP_571534.2 platelet-derived growth factor receptor alpha precursor

Status: VALIDATED

Source sequence(s)

BX276097

Related

ENSDARP00000094286.4, ENSDART00000103510.5