ctnnb1 catenin (cadherin-associated protein), beta 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctnnb1provided by ZNC
Official Full Name: catenin (cadherin-associated protein), beta 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-362
See related: Ensembl:ENSDARG00000014571 AllianceGenome:ZFIN:ZDB-GENE-980526-362
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ctnnb; id:ibd2058; wu:fb73e10; wu:fi81c06; wu:fk25h01
Summary: Enables cadherin binding activity. Involved in canonical Wnt signaling pathway. Acts upstream of or within several processes, including determination of dorsal/ventral asymmetry; ectoderm development; and glomerular filtration. Located in several cellular components, including intercalated disc; microvillus; and zonula adherens. Part of catenin complex. Is expressed in several structures, including EVL; adaxial cell; brain; germ ring; and gonad. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (6182500..6249214, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (6281340..6304649, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

27-Hydroxycholesterol activates the GSK-3beta/beta-catenin signaling pathway resulting in intestinal fibrosis by inducing oxidative stress: effect of dietary interventions.
Title: 27-Hydroxycholesterol activates the GSK-3β/β-catenin signaling pathway resulting in intestinal fibrosis by inducing oxidative stress: effect of dietary interventions.
beta-Catenin Elicits Drp1-Mediated Mitochondrial Fission Activating the Pro-Apoptotic Caspase-1/IL-1beta Signalosome in Aeromonas hydrophila-Infected Zebrafish Macrophages.
Title: β-Catenin Elicits Drp1-Mediated Mitochondrial Fission Activating the Pro-Apoptotic Caspase-1/IL-1β Signalosome in Aeromonas hydrophila-Infected Zebrafish Macrophages.
Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish.
Title: Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish.
Expression of a Degradation-Resistant beta-Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation-Induced Bone Wasting.
Title: Expression of a Degradation-Resistant β-Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation-Induced Bone Wasting.
Nanog safeguards early embryogenesis against global activation of maternal beta-catenin activity by interfering with TCF factors.
Title: Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.
that redistribution of cytosolic beta-catenin by Dkk1 concomitantly drives repression of cell adhesion and inhibits beta-catenin-dependent transcriptional output
Title: Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools.
Studied apoptosis and the Wnt/beta-catenin pathway in the cases of bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) exposure in zebrafish embryos.
Title: Bisphenol A and di(2-ethylhexyl) phthalate exert divergent effects on apoptosis and the Wnt/β-catenin pathway in zebrafish embryos: A possible mechanism of endocrine disrupting chemical action.
Wnt/beta-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling in the process of neovascularization of the central nervous system and blood-brain barrier formation.
Title: Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
The results demonstrate that the argon plasma jet has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt)/beta-Catenin-signaling pathways.
Title: Harmless effects of argon plasma on caudal fin regeneration and embryogenesis of zebrafish: novel biological approaches for safe medical applications of bioplasma.
The expression of c-kit and beta-catenin suggests that erythropoietin may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Title: Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fk25h01.x1 (e-PCR)
- UniSTS:200709

fj58f01.x1 (e-PCR)
- UniSTS:188714

fb73e10.x1 (e-PCR)
- UniSTS:187444

ctnnb (e-PCR)
- UniSTS:205394

fi81c06.x1 (e-PCR)
- UniSTS:198059

ctnnb (e-PCR)
- UniSTS:238263

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IDA Inferred from Direct Assay more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell adhesion	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of dorsal/ventral asymmetry	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within determination of dorsal/ventral asymmetry	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ectoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic axis specification	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IDA Inferred from Direct Assay more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
NOT located_in desmosome	IDA Inferred from Direct Assay more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in zonula adherens	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: catenin beta-1

Names: beta-catenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131059.2 → NP_571134.2 catenin beta-1

See identical proteins and their annotated locations for NP_571134.2

Status: PROVISIONAL

Source sequence(s)

BC047815

UniProtKB/TrEMBL

Q7ZU14

Related

ENSDARP00000032935.7, ENSDART00000038495.9

Conserved Domains (3) summary

smart00185
Location:349 → 389

ARM; Armadillo/beta-catenin-like repeats

cd00020
Location:398 → 517

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:401 → 426

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

6182500..6249214 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068213885.1 → XP_068069986.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A5H1ZRJ2, A0A8M2B4T6
XM_068213884.1 → XP_068069985.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A5H1ZRJ2, A0A8M2B4T6
XM_017351314.2 → XP_017206803.1 catenin beta-1 isoform X2

UniProtKB/TrEMBL

A0A8M6Z121
XM_005157831.5 → XP_005157888.1 catenin beta-1 isoform X1

UniProtKB/TrEMBL

A0A5H1ZRJ2, A0A8M2B4T6

Related

ENSDARP00000139205.1, ENSDART00000167505.2

Conserved Domains (3) summary

smart00185
Location:349 → 389

ARM; Armadillo/beta-catenin-like repeats

cd00020
Location:407 → 526

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:410 → 435

ARM; armadillo repeat [structural motif]