actb2 actin, beta 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: actb2provided by ZNC
Official Full Name: actin, beta 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-000329-3
See related: Ensembl:ENSDARG00000037870 AllianceGenome:ZFIN:ZDB-GENE-000329-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: actbb; bact2; bactin2
Summary: Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be located in several cellular components, including cytoskeleton; dense body; and focal adhesion. Predicted to be active in actin filament. Is expressed in several structures, including brain; eye; integument; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; autosomal dominant nonsyndromic deafness 20; and thrombocytopenia. Orthologous to several human genes including ACTB (actin beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (40526044..40531020, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (40384249..40387924, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-actin 2 (bactin2) is the mRNA with the lowest variability of expression in a panel of housekeeping genes
Title: Identification of housekeeping genes suitable for gene expression analysis in the zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC117780P1 (e-PCR)
- UniSTS:270340

fb38a10 (e-PCR)
- UniSTS:187145

PMC138261P1 (e-PCR)
- UniSTS:270864

PMC340938P1 (e-PCR)
- UniSTS:273170

PMC156330P1 (e-PCR)
- UniSTS:271392

aa658676 (e-PCR)
- UniSTS:186920

PMC180915P1 (e-PCR)
- UniSTS:271667

bact2 (e-PCR)
- UniSTS:186932

PMC85361P1 (e-PCR)
- UniSTS:273471

Actb (e-PCR), detects polymorphism
- UniSTS:516679

PMC350549P3 (e-PCR)
- UniSTS:273239

bactin2 (e-PCR), detects polymorphism
- UniSTS:205675

PMC133998P8 (e-PCR)
- UniSTS:270713

fb12f11.x1 (e-PCR)
- UniSTS:202874

PMC356969P12 (e-PCR)
- UniSTS:273274

PMC20960P1 (e-PCR)
- UniSTS:272003

AW184596 (e-PCR)
- UniSTS:205751

PMC305873P2 (e-PCR)
- UniSTS:272568

PMC154439P1 (e-PCR)
- UniSTS:271310

Acta1 (e-PCR), detects polymorphism
- UniSTS:141013

PMC101699P1 (e-PCR)
- UniSTS:270062

PMC224995P1 (e-PCR)
- UniSTS:272113

aa549815 (e-PCR)
- UniSTS:186875

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of postsynaptic actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in dense body	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin, cytoplasmic 2

Names: beta-actin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.