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    CHORDC1 cysteine and histidine rich domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 26973, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CHORDC1provided by HGNC
    Official Full Name
    cysteine and histidine rich domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:14525
    See related
    Ensembl:ENSG00000110172 MIM:604353; AllianceGenome:HGNC:14525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHP1
    Summary
    Enables Hsp90 protein binding activity. Predicted to be involved in centrosome duplication; chaperone-mediated protein folding; and regulation of cellular response to heat. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 9.0), appendix (RPKM 8.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CHORDC1 in Genome Data Viewer
    Location:
    11q14.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (90200429..90223049, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (90120509..90143130, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89933597..89956217, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD56 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:89867735-89868438 Neighboring gene MPRA-validated peak1387 silencer Neighboring gene N-acetylated alpha-linked acidic dipeptidase 2 Neighboring gene uncharacterized LOC124902812 Neighboring gene NANOG hESC enhancer GRCh37_chr11:89961208-89961714 Neighboring gene Sharpr-MPRA regulatory region 337 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:89974290-89974542 Neighboring gene DISC1 fusion partner 1 Neighboring gene tubulin alpha pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CHORDC1, the novel interacting partner of tau protein. Pichlerová K, et al. Gen Physiol Biophys, 2024 Jul. PMID 38953578
    2. MicroRNA-26b inhibits hepatitis B virus transcription and replication by targeting the host factor CHORDC1 protein. Zhao F, et al. J Biol Chem, 2014 Dec 12. PMID 25342750, Free PMC Article
    3. miR-15a targets the HSP90 co-chaperone Morgana in chronic myeloid leukemia. Poggio P, et al. Sci Rep, 2024 Jul 2. PMID 38956394, Free PMC Article
    4. The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis. Fusella F, et al. Nat Commun, 2017 Nov 21. PMID 29158506, Free PMC Article
    5. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans. Shirasu K, et al. Cell, 1999 Nov 12. PMID 10571178

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-15a targets the HSP90 co-chaperone Morgana in chronic myeloid leukemia.
      Title: miR-15a targets the HSP90 co-chaperone Morgana in chronic myeloid leukemia.
    2. CHORDC1, the novel interacting partner of tau protein.
      Title: CHORDC1, the novel interacting partner of tau protein.
    3. NF-kappaB activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana.
      Title: The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.
    4. suppression of miR-26b expression up-regulates its target gene CHORDC1, which increases HBV enhancer/promoter activities and promotes viral transcription, gene expression, and replication
      Title: MicroRNA-26b inhibits hepatitis B virus transcription and replication by targeting the host factor CHORDC1 protein.
    5. morgana causes PTEN destabilization, by inhibiting ROCK activity
      Title: Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.
    6. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
      Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    8. A novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1, is characterized.
      Title: A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.
    9. This paper described the cloning of a barley CHORD containing protein, but it also described the CHORD containing proteins in other species including human and characterized the CHORD domains.
      Title: A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of cysteine and histidine-rich domain (CHORD) containing 1 (CHORDC1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with cysteine and histidine-rich domain containing 1 (CHORDC1; CHP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37289

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone-mediated protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cysteine and histidine-rich domain-containing protein 1
    Names
    CHORD-containing protein 1
    CHP-1
    chord domain-containing protein 1
    cysteine and histidine-rich domain (CHORD) containing 1
    cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
    morgana
    protein morgana

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144073.2 → NP_001137545.1  cysteine and histidine-rich domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) is shorter compared to isoform a.
      Source sequence(s)
      AF123249, BC072461, CB852298, CF146721, CK300454
      Consensus CDS
      CCDS44705.1
      Related
      ENSP00000401080.2, ENST00000457199.6
      Conserved Domains (2) summary
      cd06488
      Location:211 → 297
      p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
      pfam04968
      Location:136 → 197
      CHORD; CHORD

    2. NM_012124.3 → NP_036256.2  cysteine and histidine-rich domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_036256.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK290231, BC002339, BC072461, CB852298, CK300454
      Consensus CDS
      CCDS8289.1
      UniProtKB/Swiss-Prot
      B2R6P8, Q6IN49, Q8WVL9, Q9H3D6, Q9UHD1
      Related
      ENSP00000319255.6, ENST00000320585.11
      Conserved Domains (2) summary
      cd06488
      Location:230 → 316
      p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
      pfam04968
      Location:3 → 64
      CHORD; CHORD

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      90200429..90223049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017541.3 → XP_016873030.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd06488
      Location:116 → 202
      p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
      pfam04968
      Location:41 → 102
      CHORD; CHORD

    2. XM_047426766.1 → XP_047282722.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

    3. XM_047426767.1 → XP_047282723.1  cysteine and histidine-rich domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PPQ5
      Related
      ENSP00000436945.1, ENST00000525317.5

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_019805497.1 Reference GRCh38.p14 PATCHES

      Range
      106552..129172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332426.1 → XP_054188401.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

    2. XM_054332427.1 → XP_054188402.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

    3. XM_054332428.1 → XP_054188403.1  cysteine and histidine-rich domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PPQ5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      90120509..90143130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368421.1 → XP_054224396.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

    2. XM_054368422.1 → XP_054224397.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

    3. XM_054368423.1 → XP_054224398.1  cysteine and histidine-rich domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PPQ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UHD1.2 GenPept UniProtKB/Swiss-Prot:Q9UHD1

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