Snai1 snail family transcriptional repressor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Snai1provided by RGD
Official Full Name: snail family transcriptional repressor 1provided by RGD
Primary source: RGD:620758
See related: AllianceGenome:RGD:620758
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sna
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and kinase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hair follicle morphogenesis; negative regulation of cell differentiation involved in embryonic placenta development; and trophoblast giant cell differentiation. Predicted to be located in cytosol; nuclear lumen; and pericentric heterochromatin. Biomarker of rheumatic heart disease. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 29.2), Kidney (RPKM 12.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (176667476..176671965)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (156248479..156252969)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (164274710..164279199)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metastasis-associated protein 1 promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis by up-regulating Snail expression.
Title: Metastasis-associated protein 1 promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis by up-regulating Snail expression.
Changes in snail and SRF expression in the kidneys of diabetic rats during ageing.
Title: Changes in snail and SRF expression in the kidneys of diabetic rats during ageing.
The NRG1modified bone marrow mesenchymal stem cells (BMSCs) promoted the functional recovery of spinal cord injury (SCI). These results suggested that NRG1 significantly promoted the expression of MMP2 by upregulating the expression of Snail, and enhanced cell migration of the BMSCs conducive to the functional recovery of SCI
Title: Neuregulin‑1 impacting bone marrow mesenchymal stem cell migration is conducive to functional recovery following spinal cord injury.
HIF-1A regulates epithelial-mesenchymal transition via the Snail and beta-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis.
Title: HIF-1α regulates EMT via the Snail and β-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis.
Suggest that miR-30a target snail 1 protein may be related to atrial fibrillation-induced myocardial fibrosis.
Title: MiR-30a regulates the atrial fibrillation-induced myocardial fibrosis by targeting snail 1.
Transcription factor snail regulates tumor necrosis factor alpha-mediated synovial fibroblast activation in the rheumatoid joint.
Title: Transcription factor snail regulates tumor necrosis factor α-mediated synovial fibroblast activation in the rheumatoid joint.
Caffeine inhibits the transcriptional factor Snail-1, down-regulating profibrogenic genes, and activates Nrf2 inducing antioxidant enzymes system, preventing inflammation and fibrosis.
Title: Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine.
miR-30a negatively regulates Snai1-mediated EMT during peritoneal fibrosis in vitro and in vivo.
Title: miR-30a negatively regulates TGF-β1-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting Snai1.
Angiotensin II plays a role in glomerular injury in experimental and human diabetic nephropathy via persistent activation of Notch1 and Snail signaling in podocytes resulting in down-regulation of nephrin expression.
Title: Angiotensin II contributes to diabetic renal dysfunction in rodents and humans via Notch1/Snail pathway.
these in vitro and in vivo data identify snail as a critical mediator for rBMMSC invasion induced by PDGF-BB.
Title: Snail mediates PDGF-BB-induced invasion of rat bone marrow mesenchymal stem cells in 3D collagen and chick chorioallantoic membrane.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Snai1 (e-PCR), detects polymorphism
- UniSTS:547651

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	TAS Traceable Author Statement more info	PubMed
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within left/right pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of cell differentiation involved in embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vitamin D biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trophoblast giant cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein SNAI1

Names: snail family zinc finger 1; snail homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053805.1 → NP_446257.1 zinc finger protein SNAI1

See identical proteins and their annotated locations for NP_446257.1

Status: PROVISIONAL

Source sequence(s)

BC079210

UniProtKB/TrEMBL

E9PU82, Q6AY35

Conserved Domains (4) summary

COG5048
Location:177 → 253

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:182 → 202

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:208 → 230

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:195 → 218

zf-H2C2_2; Zinc-finger double domain