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    Ccr3 C-C motif chemokine receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117027, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Ccr3provided by RGD
    Official Full Name
    C-C motif chemokine receptor 3provided by RGD
    Primary source
    RGD:620593
    See related
    EnsemblRapid:ENSRNOG00000006736 AllianceGenome:RGD:620593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cmkbr3
    Summary
    Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Involved in ERK1 and ERK2 cascade; angioblast cell migration; and leukocyte chemotaxis. Located in endosome and extracellular space. Used to study asthma and myocardial infarction. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif chemokine receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 240.1) and Uterus (RPKM 12.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccr3 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (132463533..132511601)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (123586100..123634178)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (133026539..133040999)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transcription initiation factor TFIID subunit 13-like Neighboring gene C-C motif chemokine receptor 1 Neighboring gene chemokine (C-C motif) receptor 1-like 1 Neighboring gene Tarbp2 subunit of RISC loading complex, pseudogene 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like Neighboring gene C-C motif chemokine receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis. Liclican EL, et al. Invest Ophthalmol Vis Sci, 2010 Dec. PMID 20610836, Free PMC Article
    2. Treatment with anti-CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34 progenitor cells in an allergic mouse model. Ben S, et al. Allergy, 2008 Sep. PMID 18699933
    3. Transcriptional analyses before and after suppression of immediate hypersensitivity reactions by CCR3 blockade in eyes with experimental allergic conjunctivitis. Komatsu N, et al. Invest Ophthalmol Vis Sci, 2008 Dec. PMID 18658092
    4. Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B infection. TrehanPati N, et al. Hepatology, 2009 Mar. PMID 19185001
    5. Pinellia ternata, Citrus reticulata, and their combinational prescription inhibit eosinophil infiltration and airway hyperresponsiveness by suppressing CCR3+ and Th2 cytokines production in the ovalbumin-induced asthma model. Ok IS, et al. Mediators Inflamm, 2009. PMID 19657453, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain.
      Title: Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain.
    2. CCR3 levels in EAE rats were significantly increased. CCR3 levels in brain tissues were positively correlated with the inflammatory scores.
      Title: CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis.
    3. our data suggest that the CCL11-CCR3 interaction mainly activates PI3K/Akt signal transduction pathway in HUVECs.
      Title: CCL11 promotes angiogenic activity by activating the PI3K/Akt pathway in HUVECs.
    4. CCR3 plays no role in choroidal neovascularization development.
      Title: What is the role of CCR3 in choroidal neovascularization?
    5. The expression of Eotaxin in nasal mucosa increased, and the expression of CCR3 in bone marrow increased in the model of allergic rhinitis.
      Title: [The expression and significance of eotaxin gene in nasal mucosa and CCR3 in bone marrow in model of allergic rhinitis].
    6. Allergen-induced recruitment of eosinophils in the distal septum and turbinates was maximal at 8h post-challenge, and was correlated with 2-4-fold increase in CCR3 and betac mRNA
      Title: Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis.
    7. Down-regulation of constitutively expressed surface CCR3 levels by interleukin 1-beta in an insulin-producing model system implies receptor internalization for re-utilization or destruction, secretion or both.
      Title: Localization and expression of CCR3 and CCR5 by interleukin-1 beta in the RIN-5AH insulin-producing model system: a protective mechanism involving down-regulation of chemokine receptors.
    8. demonstrated that CCR3 is absent from the testes
      Title: Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables C-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in angioblast cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in eosinophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mast cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-C chemokine receptor type 3
    Names
    C-C CKR-3
    CC-CKR-3
    CCR-3
    CKR3
    chemokine (C-C motif) receptor 3
    chemokine (C-C) receptor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053958.2 → NP_446410.1  C-C chemokine receptor type 3

      See identical proteins and their annotated locations for NP_446410.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O54814, O55169
      UniProtKB/TrEMBL
      A0A0A0MXU9, A6I4D1
      Related
      ENSRNOP00000105067.1, ENSRNOT00000165685.1
      Conserved Domains (1) summary
      cd15185
      Location:39 → 316
      7tmA_CCR3; CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      132463533..132511601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080707.2 → XP_038936635.1  C-C chemokine receptor type 3 isoform X1

      UniProtKB/Swiss-Prot
      O54814, O55169
      UniProtKB/TrEMBL
      A0A0A0MXU9, A6I4D1
      Related
      ENSRNOP00000103876.1, ENSRNOT00000131707.1
      Conserved Domains (1) summary
      cd15185
      Location:39 → 316
      7tmA_CCR3; CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_039080708.2 → XP_038936636.1  C-C chemokine receptor type 3 isoform X1

      UniProtKB/Swiss-Prot
      O54814, O55169
      UniProtKB/TrEMBL
      A0A0A0MXU9, A6I4D1
      Related
      ENSRNOP00000110031.1, ENSRNOT00000121928.1
      Conserved Domains (1) summary
      cd15185
      Location:39 → 316
      7tmA_CCR3; CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_063264781.1 → XP_063120851.1  C-C chemokine receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MXU9, A6I4D1
      Related
      ENSRNOP00000008809.4, ENSRNOT00000008809.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54814.1 GenPept UniProtKB/Swiss-Prot:O54814

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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