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    TAS2R60 taste 2 receptor member 60 [ Homo sapiens (human) ]

    Gene ID: 338398, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAS2R60provided by HGNC
    Official Full Name
    taste 2 receptor member 60provided by HGNC
    Primary source
    HGNC:HGNC:20639
    See related
    Ensembl:ENSG00000185899 MIM:613968; AllianceGenome:HGNC:20639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R56; T2R60
    Summary
    This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. [provided by RefSeq, Jul 2017]
    Orthologs
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    Genomic context

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    See TAS2R60 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143443453..143444409)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144798817..144799773)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143140546..143141502)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143088659-143089259 Neighboring gene Sharpr-MPRA regulatory region 10434 Neighboring gene Sharpr-MPRA regulatory region 2529 Neighboring gene EPH receptor A1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143101922-143102436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143106021-143106633 Neighboring gene EPHA1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12322 Neighboring gene taste 2 receptor member 62 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:143169186-143170385 Neighboring gene taste 2 receptor member 41 Neighboring gene olfactory receptor family 2 subfamily R member 1, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Thalmann S, et al. Biochem Biophys Res Commun, 2013 May 31. PMID 23632330
    2. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Conte C, et al. Cytogenet Genome Res, 2002. PMID 12584440
    3. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article
    4. The molecular receptive ranges of human TAS2R bitter taste receptors. Meyerhof W, et al. Chem Senses, 2010 Feb. PMID 20022913
    5. Receptors for bitter and sweet taste. Montmayeur JP, et al. Curr Opin Neurobiol, 2002 Aug. PMID 12139982

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119154, MGC119155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    NOT enables bitter taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of bitter taste NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    taste receptor type 2 member 60
    Names
    taste receptor type 2 member 56
    taste receptor, type 2, member 60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177437.1 → NP_803186.1  taste receptor type 2 member 60

      See identical proteins and their annotated locations for NP_803186.1

      Status: REVIEWED

      Source sequence(s)
      AY114094
      Consensus CDS
      CCDS5885.1
      UniProtKB/Swiss-Prot
      A4D2G8, P59551, Q645W8, Q7RTR7
      UniProtKB/TrEMBL
      Q50KC8
      Related
      ENSP00000327724.1, ENST00000332690.1
      Conserved Domains (1) summary
      cd15018
      Location:31 → 308
      7tm_TAS2R41-like; mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      143443453..143444409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654714.1 Reference GRCh38.p14 PATCHES

      Range
      62817..63773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      144798817..144799773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59551.1 GenPept UniProtKB/Swiss-Prot:P59551

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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