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    GRAMD1B GRAM domain containing 1B [ Homo sapiens (human) ]

    Gene ID: 57476, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GRAMD1Bprovided by HGNC
    Official Full Name
    GRAM domain containing 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:29214
    See related
    Ensembl:ENSG00000023171 MIM:620179; AllianceGenome:HGNC:29214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC01059
    Summary
    Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal (RPKM 12.4), duodenum (RPKM 5.7) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GRAMD1B in Genome Data Viewer
    Location:
    11q24.1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (123358422..123627767)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (123386861..123656743)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (123229130..123498475)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4014 Neighboring gene PHB1 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5678 Neighboring gene Sharpr-MPRA regulatory region 995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5681 Neighboring gene NANOG hESC enhancer GRCh37_chr11:123275922-123276438 Neighboring gene microRNA 4493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:123278189-123279097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5683 Neighboring gene uncharacterized LOC124902776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4016 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:123313949-123314928 Neighboring gene Sharpr-MPRA regulatory region 13459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5686 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123364173-123364689 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123364690-123365206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4018 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:123407917-123408491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123430192-123430855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123430856-123431518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123431519-123432182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123446989-123447488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123446487-123446988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123448087-123448624 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:123449825-123450047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123450909-123451518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123474209-123474708 Neighboring gene splicing factor 3a, subunit 3 pseudogene 2 Neighboring gene uncharacterized LOC124902777 Neighboring gene uncharacterized LOC105369543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4021 Neighboring gene sodium voltage-gated channel beta subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Aster proteins mediate carotenoid transport in mammalian cells. Bandara S, et al. Proc Natl Acad Sci U S A, 2022 Apr 12. PMID 35394870, Free PMC Article
    2. Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b. Ercan B, et al. EMBO J, 2021 Mar 15. PMID 33604931, Free PMC Article
    3. GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling. Khanna P, et al. Sci Rep, 2018 Jun 22. PMID 29934528, Free PMC Article
    4. Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport. Andersen JP, et al. Mol Metab, 2020 Dec. PMID 32738348, Free PMC Article
    5. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Conde L, et al. Nat Genet, 2010 Aug. PMID 20639881, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aster proteins mediate carotenoid transport in mammalian cells.
      Title: Aster proteins mediate carotenoid transport in mammalian cells.
    2. Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.
      Title: Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.
    3. Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport.
      Title: Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport.
    4. Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression.
      Title: Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression.
    5. GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling
      Title: GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1201, MGC125622, MGC125623, MGC125625, AP000783.2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cholesterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum-plasma membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Aster-B
    Names
    Aster-B
    GRAM domain-containing protein 1B
    long intergenic non-protein coding RNA 1059

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286563.3 → NP_001273492.1  protein Aster-B isoform 1

      See identical proteins and their annotated locations for NP_001273492.1

      Status: VALIDATED

      Source sequence(s)
      AK127457, AP000841, AP002765, BC107480
      Consensus CDS
      CCDS66253.1
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Related
      ENSP00000402457.2, ENST00000456860.6
      Conserved Domains (2) summary
      cd13220
      Location:114 → 207
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:382 → 530
      DUF4782; Domain of unknown function (DUF4782)

    2. NM_001286564.3 → NP_001273493.1  protein Aster-B isoform 3

      See identical proteins and their annotated locations for NP_001273493.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 18 and 19, encodes isoform 3.
      Source sequence(s)
      AB033027, AK297606, AP002765
      Consensus CDS
      CCDS66254.1
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Related
      ENSP00000432987.1, ENST00000529432.5
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    3. NM_001330396.3 → NP_001317325.1  protein Aster-B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 20 and 21, encodes isoform 4.
      Source sequence(s)
      AP000841, AP002765
      Consensus CDS
      CCDS81640.1
      UniProtKB/TrEMBL
      A0A024R3M2, A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    4. NM_001354837.2 → NP_001341766.1  protein Aster-B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AP000783, BI256024, BU622943
      Consensus CDS
      CCDS86254.1
      UniProtKB/TrEMBL
      A0A1B0GVV0
      Related
      ENSP00000490665.1, ENST00000533341.3

    5. NM_001367418.2 → NP_001354347.1  protein Aster-B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AP000841, AP001782, AP002765
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:134 → 227
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:402 → 550
      DUF4782; Domain of unknown function (DUF4782)

    6. NM_001367419.2 → NP_001354348.1  protein Aster-B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AP000841, AP001782, AP002765
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:134 → 227
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:402 → 550
      DUF4782; Domain of unknown function (DUF4782)

    7. NM_001367420.2 → NP_001354349.1  protein Aster-B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AP000841, AP001782, AP002765
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:134 → 227
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:402 → 550
      DUF4782; Domain of unknown function (DUF4782)

    8. NM_001367421.2 → NP_001354350.1  protein Aster-B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AP000783, AP000841, AP001782, AP002765
      UniProtKB/TrEMBL
      A0A1B0GWG7

    9. NM_001387024.1 → NP_001373953.1  protein Aster-B isoform 10

      Status: VALIDATED

      Source sequence(s)
      AP000783, AP000841, AP002765
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:250 → 343
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:518 → 666
      DUF4782; Domain of unknown function (DUF4782)

    10. NM_001387025.1 → NP_001373954.1  protein Aster-B isoform 11

      Status: VALIDATED

      Source sequence(s)
      AP000783, AP000841, AP002765
      Consensus CDS
      CCDS91613.1
      UniProtKB/TrEMBL
      A0A1B0GUD6, A0A1B0GWG7
      Related
      ENSP00000490062.1, ENST00000635736.2
      Conserved Domains (2) summary
      cd13220
      Location:250 → 343
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:518 → 666
      DUF4782; Domain of unknown function (DUF4782)

    11. NM_001387026.1 → NP_001373955.1  protein Aster-B isoform 12

      Status: VALIDATED

      Source sequence(s)
      AP000783, AP000841, AP002765
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:249 → 342
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:517 → 665
      DUF4782; Domain of unknown function (DUF4782)

    12. NM_001387028.1 → NP_001373957.1  protein Aster-B isoform 13

      Status: VALIDATED

      Source sequence(s)
      AP000841, AP002765
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:107 → 200
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:375 → 523
      DUF4782; Domain of unknown function (DUF4782)

    13. NM_001387029.1 → NP_001373958.1  protein Aster-B isoform 14

      Status: VALIDATED

      Source sequence(s)
      AP000841, AP002765
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:107 → 200
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:375 → 523
      DUF4782; Domain of unknown function (DUF4782)

    14. NM_001387030.1 → NP_001373959.1  protein Aster-B isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform 15.
      Source sequence(s)
      AP000783, AP000841, AP002765
      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    15. NM_001387031.1 → NP_001373960.1  protein Aster-B isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform 15.
      Source sequence(s)
      AP002765
      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    16. NM_001387032.1 → NP_001373961.1  protein Aster-B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 3 and 18, encodes isoform 3.
      Source sequence(s)
      AP000841, AP002765
      Consensus CDS
      CCDS66254.1
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    17. NM_001387033.1 → NP_001373962.1  protein Aster-B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 3 and 17, encodes isoform 3.
      Source sequence(s)
      AP000841, AP002765
      Consensus CDS
      CCDS66254.1
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Related
      ENSP00000490920.1, ENST00000638086.1
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    18. NM_001387034.1 → NP_001373963.1  protein Aster-B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 4 and 20, encodes isoform 4.
      Source sequence(s)
      AP000783, AP000841, AP002765
      Consensus CDS
      CCDS81640.1
      UniProtKB/TrEMBL
      A0A024R3M2, A0A1B0GWG7
      Related
      ENSP00000489896.1, ENST00000638157.1
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    19. NM_001387035.1 → NP_001373964.1  protein Aster-B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variants 4 and 19, encodes isoform 4.
      Source sequence(s)
      AP002765
      Consensus CDS
      CCDS81640.1
      UniProtKB/TrEMBL
      A0A024R3M2, A0A1B0GWG7
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    20. NM_020716.4 → NP_065767.1  protein Aster-B isoform 2

      See identical proteins and their annotated locations for NP_065767.1

      Status: VALIDATED

      Source sequence(s)
      AI815988, AK127457, AP000841, AP002765, BC107480
      Consensus CDS
      CCDS53720.1
      UniProtKB/Swiss-Prot
      B3KXJ5, E7EPH8, Q3KR37, Q6UW85, Q9ULL9
      UniProtKB/TrEMBL
      A0A1B0GWG7
      Related
      ENSP00000436500.1, ENST00000529750.5
      Conserved Domains (2) summary
      cd13220
      Location:107 → 200
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:375 → 523
      DUF4782; Domain of unknown function (DUF4782)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      123358422..123627767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427319.1 → XP_047283275.1  protein Aster-B isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWG7

    2. XM_047427324.1 → XP_047283280.1  protein Aster-B isoform X5

      UniProtKB/TrEMBL
      B7Z4N9

    3. XM_017018039.2 → XP_016873528.1  protein Aster-B isoform X10

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:134 → 227
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:406 → 550
      DUF4782; Domain of unknown function (DUF4782)

    4. XM_024448622.2 → XP_024304390.1  protein Aster-B isoform X12

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:108 → 201
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:380 → 524
      DUF4782; Domain of unknown function (DUF4782)

    5. XM_047427323.1 → XP_047283279.1  protein Aster-B isoform X5

      UniProtKB/TrEMBL
      B7Z4N9

    6. XM_006718892.4 → XP_006718955.1  protein Aster-B isoform X7

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:150 → 243
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:422 → 566
      DUF4782; Domain of unknown function (DUF4782)

    7. XM_011542926.3 → XP_011541228.1  protein Aster-B isoform X8

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:149 → 242
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:421 → 565
      DUF4782; Domain of unknown function (DUF4782)

    8. XM_017018040.2 → XP_016873529.1  protein Aster-B isoform X11

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:124 → 217
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:396 → 540
      DUF4782; Domain of unknown function (DUF4782)

    9. XM_047427322.1 → XP_047283278.1  protein Aster-B isoform X4

      UniProtKB/TrEMBL
      A0A1B0GWG7

    10. XM_047427320.1 → XP_047283276.1  protein Aster-B isoform X2

      UniProtKB/TrEMBL
      B7Z4N9

    11. XM_047427321.1 → XP_047283277.1  protein Aster-B isoform X3

      UniProtKB/TrEMBL
      B7Z4N9

    12. XM_047427318.1 → XP_047283274.1  protein Aster-B isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWG7

    13. XM_047427327.1 → XP_047283283.1  protein Aster-B isoform X9

      UniProtKB/TrEMBL
      A0A1B0GWG7

    14. XM_047427325.1 → XP_047283281.1  protein Aster-B isoform X6

      UniProtKB/TrEMBL
      B7Z4N9

    15. XM_047427330.1 → XP_047283286.1  protein Aster-B isoform X20

      UniProtKB/TrEMBL
      A0A1B0GWG7

    16. XM_047427326.1 → XP_047283282.1  protein Aster-B isoform X18

      UniProtKB/TrEMBL
      B7Z4N9

    17. XM_017018046.2 → XP_016873535.1  protein Aster-B isoform X15

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    18. XM_011542931.3 → XP_011541233.1  protein Aster-B isoform X15

      See identical proteins and their annotated locations for XP_011541233.1

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:67 → 160
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:335 → 483
      DUF4782; Domain of unknown function (DUF4782)

    19. XM_005271619.5 → XP_005271676.1  protein Aster-B isoform X13

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:107 → 200
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:379 → 523
      DUF4782; Domain of unknown function (DUF4782)

    20. XM_047427328.1 → XP_047283284.1  protein Aster-B isoform X19

      UniProtKB/TrEMBL
      B7Z4N9

    21. XM_011542929.3 → XP_011541231.1  protein Aster-B isoform X14

      UniProtKB/TrEMBL
      B7Z4N9
      Conserved Domains (2) summary
      cd13220
      Location:103 → 196
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:375 → 519
      DUF4782; Domain of unknown function (DUF4782)

    22. XM_011542933.2 → XP_011541235.1  protein Aster-B isoform X16

      UniProtKB/TrEMBL
      A0A1B0GWG7, A0A2R8Y5X2
      Related
      ENSP00000494891.1, ENST00000646146.1
      Conserved Domains (2) summary
      cd13220
      Location:71 → 164
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:343 → 487
      DUF4782; Domain of unknown function (DUF4782)

    23. XM_047427331.1 → XP_047283287.1  protein Aster-B isoform X17

      UniProtKB/TrEMBL
      A0A1B0GWG7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      123386861..123656743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369457.1 → XP_054225432.1  protein Aster-B isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWG7

    2. XM_054369462.1 → XP_054225437.1  protein Aster-B isoform X5

      UniProtKB/TrEMBL
      B7Z4N9

    3. XM_054369468.1 → XP_054225443.1  protein Aster-B isoform X10

      UniProtKB/TrEMBL
      B7Z4N9

    4. XM_054369472.1 → XP_054225447.1  protein Aster-B isoform X12

      UniProtKB/TrEMBL
      B7Z4N9

    5. XM_054369461.1 → XP_054225436.1  protein Aster-B isoform X5

      UniProtKB/TrEMBL
      B7Z4N9

    6. XM_054369470.1 → XP_054225445.1  protein Aster-B isoform X11

      UniProtKB/TrEMBL
      B7Z4N9

    7. XM_054369465.1 → XP_054225440.1  protein Aster-B isoform X7

      UniProtKB/TrEMBL
      B7Z4N9

    8. XM_054369466.1 → XP_054225441.1  protein Aster-B isoform X8

      UniProtKB/TrEMBL
      B7Z4N9

    9. XM_054369460.1 → XP_054225435.1  protein Aster-B isoform X4

      UniProtKB/TrEMBL
      A0A1B0GWG7

    10. XM_054369458.1 → XP_054225433.1  protein Aster-B isoform X2

      UniProtKB/TrEMBL
      B7Z4N9

    11. XM_054369459.1 → XP_054225434.1  protein Aster-B isoform X3

      UniProtKB/TrEMBL
      B7Z4N9

    12. XM_054369467.1 → XP_054225442.1  protein Aster-B isoform X9

      UniProtKB/TrEMBL
      A0A1B0GWG7

    13. XM_054369463.1 → XP_054225438.1  protein Aster-B isoform X6

      UniProtKB/TrEMBL
      B7Z4N9

    14. XM_054369464.1 → XP_054225439.1  protein Aster-B isoform X21

      UniProtKB/TrEMBL
      B7Z4N9

    15. XM_054369471.1 → XP_054225446.1  protein Aster-B isoform X23

      UniProtKB/TrEMBL
      A0A1B0GWG7

    16. XM_054369476.1 → XP_054225451.1  protein Aster-B isoform X15

      UniProtKB/TrEMBL
      B7Z4N9

    17. XM_054369478.1 → XP_054225453.1  protein Aster-B isoform X15

      UniProtKB/TrEMBL
      B7Z4N9

    18. XM_054369481.1 → XP_054225456.1  protein Aster-B isoform X25

      UniProtKB/TrEMBL
      A0A024R3M2, A0A1B0GWG7

    19. XM_054369474.1 → XP_054225449.1  protein Aster-B isoform X13

      UniProtKB/TrEMBL
      B7Z4N9

    20. XM_054369469.1 → XP_054225444.1  protein Aster-B isoform X22

      UniProtKB/TrEMBL
      B7Z4N9

    21. XM_054369473.1 → XP_054225448.1  protein Aster-B isoform X24

      UniProtKB/TrEMBL
      A0A1B0GWG7

    22. XM_054369475.1 → XP_054225450.1  protein Aster-B isoform X14

      UniProtKB/TrEMBL
      B7Z4N9

    23. XM_054369477.1 → XP_054225452.1  protein Aster-B isoform X15

      UniProtKB/TrEMBL
      B7Z4N9

    24. XM_054369479.1 → XP_054225454.1  protein Aster-B isoform X16

      UniProtKB/TrEMBL
      A0A1B0GWG7, A0A2R8Y5X2

    25. XM_054369480.1 → XP_054225455.1  protein Aster-B isoform X17

      UniProtKB/TrEMBL
      A0A1B0GWG7

    26. XM_054369482.1 → XP_054225457.1  protein Aster-B isoform X26

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KR37.1 GenPept UniProtKB/Swiss-Prot:Q3KR37

    Gene LinkOut

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