MRNIP MRN complex interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: MRNIPprovided by HGNC
Official Full Name: MRN complex interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:30817
See related: Ensembl:ENSG00000161010 MIM:617154; AllianceGenome:HGNC:30817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C5orf45
Summary: Enables chromatin binding activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of protein kinase activity; and regulation of double-strand break repair. Located in Mre11 complex and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in endometrium (RPKM 41.9), lung (RPKM 28.1) and 25 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5q35.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (179837276..179858817, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (180392487..180413966, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (179264276..179285817, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these data reveal that MRNIP is an important component of the human DNA damage response.
Title: MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
Knockdown of chromosome 5 open reading frame 45 (C5orf45) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

GDB:312794 (e-PCR)
- UniSTS:30247

SHGC-33017 (e-PCR)
- UniSTS:55337

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D10S16 (e-PCR)
- UniSTS:155756

G35510 (e-PCR)
- UniSTS:44150

D11S4452 (e-PCR)
- UniSTS:154758

D5S2306E (e-PCR)
- UniSTS:154514

A008T21 (e-PCR)
- UniSTS:49555

RH70719 (e-PCR)
- UniSTS:27561

G44365 (e-PCR)
- UniSTS:95151

L18441 (e-PCR)
- UniSTS:71348

D22S296 (e-PCR)
- UniSTS:147641

RH18060 (e-PCR)
- UniSTS:14267

WI-22658 (e-PCR)
- UniSTS:33730

SQSTM1_8870 (e-PCR)
- UniSTS:467911

D3S4354 (e-PCR)
- UniSTS:474102

A002O27 (e-PCR)
- UniSTS:21750

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromatin	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Mre11 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: MRN complex-interacting protein

Names: MRN-interacting protein; UPF0544 protein C5orf45

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017987.3 → NP_001017987.1 MRN complex-interacting protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons in the coding region, as compared to variant 1. The encoded isoform (2) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

BC050714, BC056889, BC069051, BF965313, BQ642639

Consensus CDS

CCDS34318.1

UniProtKB/Swiss-Prot

Q6NTE8

Related

ENSP00000366130.2, ENST00000376931.6

Conserved Domains (1) summary

pfam15749
Location:9 → 43

UPF0544; uncharacterized protein family UPF0544
NM_016175.4 → NP_057259.2 MRN complex-interacting protein isoform 1

See identical proteins and their annotated locations for NP_057259.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC050714, BC069051, BF965313, BQ642639

Consensus CDS

CCDS34319.1

UniProtKB/Swiss-Prot

B5MD09, E9PAK6, Q6NTE8, Q7Z3D8, Q9BUC1, Q9UN54

Related

ENSP00000292586.6, ENST00000292586.11

Conserved Domains (1) summary

pfam15749
Location:9 → 107

UPF0544; uncharacterized protein family UPF0544

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

179837276..179858817 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

NW_016107298.1 Reference GRCh38.p14 PATCHES

Range

602836..624377 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

180392487..180413966 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001018061.1: Suppressed sequence

Description

NM_001018061.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_001018062.1: Suppressed sequence

Description

NM_001018062.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.