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    ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 6484, updated on 12-Dec-2024

    Summary

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    Official Symbol
    ST3GAL4provided by HGNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:10864
    See related
    Ensembl:ENSG00000110080 MIM:104240; AllianceGenome:HGNC:10864
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STZ; SAT3; ST-4; CGS23; SIAT4; NANTA3; SIAT4C; ST3GalIV; ST3GalA.2; gal-NAc6S
    Summary
    This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in adrenal (RPKM 20.2), ovary (RPKM 18.9) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ST3GAL4 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (126355686..126414638)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (126387091..126446076)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126225581..126284533)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5708 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:126185709-126185914 Neighboring gene TIRAP antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126197556-126198280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126198281-126199003 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126203043-126203544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126204673-126205174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126207449-126208010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126206322-126206884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126206885-126207448 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:126208933-126210132 Neighboring gene TIR domain containing adaptor protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126224473-126225216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126225217-126225958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126225959-126226702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126228189-126228930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126234481-126234998 Neighboring gene decapping enzyme, scavenger Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126263623-126264550 Neighboring gene Sharpr-MPRA regulatory region 5906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4052 Neighboring gene G-quadruplex forming sequence containing lncRNA Neighboring gene ReSE screen-validated silencer GRCh37_chr11:126304382-126304547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126306384-126307384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126312444-126313126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126314549-126315102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126315103-126315656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126316770-126317338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126336189-126336738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126336739-126337286 Neighboring gene kirre like nephrin family adhesion molecule 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126348793-126349294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126356175-126356675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126364262-126365032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126389731-126390232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126393473-126393972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126398704-126399204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126399205-126399705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126413360-126413866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126413867-126414371 Neighboring gene KIRREL3 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:126434244-126434929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126437665-126438165 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126455626-126456345 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126456346-126457066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126457067-126457785 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126462463-126462992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126462993-126463521 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:126471727-126472504 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:126477093-126477778 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:126477779-126478464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126478465-126479149 Neighboring gene uncharacterized LOC101929427

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibition of H5N1 highly pathogenic influenza virus by suppressing a specific sialyltransferase. Monteerarat Y, et al. Arch Virol, 2010 Jun. PMID 20383541
    2. Role of a Disease-associated ST3Gal-4 in Non-small Cell Lung Cancer. Singh P, et al. Cell Biochem Biophys, 2022 Dec. PMID 36083411
    3. ST3GAL4 promotes tumorigenesis in breast cancer by enhancing aerobic glycolysis. Chen X, et al. Hum Cell, 2024 Oct 18. PMID 39422756
    4. Transcriptional regulation of human Galbeta1,3GalNAc/Galbeta1, 4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene in testis and ovary cell lines. Taniguchi A, et al. Biochem Biophys Res Commun, 2003 Feb 14. PMID 12565846
    5. Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues. Grahn A, et al. Glycoconj J, 2001 Oct. PMID 12441665

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ST3GAL4 promotes tumorigenesis in breast cancer by enhancing aerobic glycolysis.
      Title: ST3GAL4 promotes tumorigenesis in breast cancer by enhancing aerobic glycolysis.
    2. ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility.
      Title: ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility.
    3. Role of a Disease-associated ST3Gal-4 in Non-small Cell Lung Cancer.
      Title: Role of a Disease-associated ST3Gal-4 in Non-small Cell Lung Cancer.
    4. MiR-193b modulates osteoarthritis progression through targeting ST3GAL4 via sialylation of CD44 and NF-small ka, CyrillicB pathway.
      Title: MiR-193b modulates osteoarthritis progression through targeting ST3GAL4 via sialylation of CD44 and NF-кB pathway.
    5. Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation.
      Title: Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation.
    6. Identification and characterization of the V3 promoter of the ST3GAL4 gene.
      Title: Identification and characterization of the V3 promoter of the ST3GAL4 gene.
    7. a cross-restoration of each of the three genes in ST3GAL6 KO cells showed that overexpression of ST3GAL6 sufficiently rescued the total alpha2,3-sialylation levels, cell morphology, and alpha2,3-sialylation of EGFR, whereas the alpha2,3-sialylation levels of beta1 were greatly enhanced by an overexpression of ST3GAL4
      Title: ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.
    8. MiR-193a-3p and miR-224 promoted the cell proliferation and decreased apoptosis by targeting alpha-2,3-sialyltransferase IV in renal cell carcinoma.
      Title: MiR-193a-3p and miR-224 mediate renal cell carcinoma progression by targeting alpha-2,3-sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway.
    9. The V1 transcript of the ST3GAL4 demonstrated significant decreased expression in premalignant and malignant cervical tissues.
      Title: Expression analysis of ST3GAL4 transcripts in cervical cancer cells.
    10. study illustrates the power of next-generation sequencing in the discovery of new genetic variants and a significant ethnic diversity in the ST3GAL4 gene
      Title: Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    EBI GWAS Catalog
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11867, FLJ46764

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
    		  
    involved_in cognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycoprotein biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in keratan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in lipid glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in positive regulation of blood coagulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sialylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sialylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral protein processing TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
    Names
    N-acetyllactosaminide alpha-2,3-sialyltransferase
    alpha 2,3-ST 4
    alpha 2,3-sialyltransferase IV
    alpha-3-N-acetylneuraminyltransferase
    beta-galactoside alpha-2,3-sialyltransferase 4
    gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
    gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase
    sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)
    sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase)
    NP_001241686.1
    NP_001241687.1
    NP_001241688.1
    NP_001335325.1
    NP_001335326.1
    NP_001335327.1
    NP_001335328.1
    NP_001335329.1
    NP_006269.1
    XP_024304426.1
    XP_047283374.1
    XP_047283376.1
    XP_047283377.1
    XP_047283378.1
    XP_047283379.1
    XP_047283380.1
    XP_047283381.1
    XP_047283382.1
    XP_054225628.1
    XP_054225629.1
    XP_054225630.1
    XP_054225631.1
    XP_054225632.1
    XP_054225633.1
    XP_054225634.1
    XP_054225635.1
    XP_054225636.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053025.1 RefSeqGene

      Range
      5042..63994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001254757.2 → NP_001241686.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

      See identical proteins and their annotated locations for NP_001241686.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 3 and 8, encodes isoform 2.
      Source sequence(s)
      AL520639, AL529887, AP000806, BI259855, BP320415
      Consensus CDS
      CCDS58193.1
      UniProtKB/Swiss-Prot
      A8K6B2, O60497, Q11206, Q8N6A6, Q8NFG7, Q96QQ9
      UniProtKB/TrEMBL
      Q8NFD3
      Related
      ENSP00000394354.2, ENST00000444328.7
      Conserved Domains (1) summary
      pfam00777
      Location:87 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001254758.2 → NP_001241687.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

      See identical proteins and their annotated locations for NP_001241687.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 2 and 8, encodes isoform 2.
      Source sequence(s)
      BC010645
      Consensus CDS
      CCDS58193.1
      UniProtKB/Swiss-Prot
      A8K6B2, O60497, Q11206, Q8N6A6, Q8NFG7, Q96QQ9
      UniProtKB/TrEMBL
      Q8NFD3
      Related
      ENSP00000376437.2, ENST00000392669.6
      Conserved Domains (1) summary
      pfam00777
      Location:87 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_001254759.2 → NP_001241688.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 3

      See identical proteins and their annotated locations for NP_001241688.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform 3.
      Source sequence(s)
      AP000806, DA841563, L23767
      Consensus CDS
      CCDS58194.1
      UniProtKB/TrEMBL
      Q8NFD3
      Related
      ENSP00000434349.1, ENST00000532243.5
      Conserved Domains (1) summary
      pfam00777
      Location:104 → 330
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_001348396.2 → NP_001335325.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform 4.
      Source sequence(s)
      AP000806, AP001318
      Consensus CDS
      CCDS91621.1
      UniProtKB/TrEMBL
      A0A7P0RGI5, Q8NFD3
      Conserved Domains (1) summary
      pfam00777
      Location:108 → 352
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. NM_001348397.2 → NP_001335326.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (4). Variants 5 and 6 both encode the same isoform (4).
      Source sequence(s)
      AP000806, AP001318
      Consensus CDS
      CCDS91621.1
      UniProtKB/TrEMBL
      A0A7P0RGI5, Q8NFD3
      Related
      ENSP00000348451.5, ENST00000356132.9
      Conserved Domains (1) summary
      pfam00777
      Location:108 → 352
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. NM_001348398.2 → NP_001335327.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform 5.
      Source sequence(s)
      AP000806, AP001318
      Consensus CDS
      CCDS91622.1
      UniProtKB/TrEMBL
      A0A7I2V4V4, A0A7I2V5F3
      Related
      ENSP00000504548.1, ENST00000677503.1
      Conserved Domains (1) summary
      pfam00777
      Location:101 → 233
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. NM_001348399.2 → NP_001335328.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 2, and 3, encodes isoform 2.
      Source sequence(s)
      AP000806, AP001318
      Consensus CDS
      CCDS58193.1
      UniProtKB/Swiss-Prot
      A8K6B2, O60497, Q11206, Q8N6A6, Q8NFG7, Q96QQ9
      UniProtKB/TrEMBL
      Q8NFD3
      Related
      ENSP00000433318.1, ENST00000534083.5
      Conserved Domains (1) summary
      pfam00777
      Location:87 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. NM_001348400.2 → NP_001335329.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), along with variant 1, encodes isoform 1.
      Source sequence(s)
      AP000806, AP001318
      Consensus CDS
      CCDS8474.1
      UniProtKB/TrEMBL
      Q6IBE6, Q8NFD3
      Related
      ENSP00000227495.6, ENST00000227495.10
      Conserved Domains (1) summary
      pfam00777
      Location:101 → 327
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    9. NM_006278.3 → NP_006269.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1

      See identical proteins and their annotated locations for NP_006269.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variant 9, encodes isoform 1.
      Source sequence(s)
      AP000806, AP001318, X74570
      Consensus CDS
      CCDS8474.1
      UniProtKB/TrEMBL
      Q6IBE6, Q8NFD3
      Related
      ENSP00000433989.1, ENST00000530591.5
      Conserved Domains (1) summary
      pfam00777
      Location:101 → 327
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. NR_145671.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) does not encode a protein.
      Source sequence(s)
      AP000806, AP001318
      Related
      ENST00000676867.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      126355686..126414638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427426.1 → XP_047283382.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X8

      UniProtKB/TrEMBL
      Q8NFD3

    2. XM_047427425.1 → XP_047283381.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X7

      UniProtKB/TrEMBL
      Q8NFD3

    3. XM_047427423.1 → XP_047283379.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X5

      UniProtKB/TrEMBL
      A0A7P0RGI5, Q8NFD3

    4. XM_047427421.1 → XP_047283377.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X3

      UniProtKB/TrEMBL
      Q8NFD3

    5. XM_047427418.1 → XP_047283374.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      A8K6B2, O60497, Q11206, Q8N6A6, Q8NFG7, Q96QQ9
      UniProtKB/TrEMBL
      Q8NFD3
      Related
      ENSP00000436047.1, ENST00000526727.5

    6. XM_024448658.2 → XP_024304426.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      A8K6B2, O60497, Q11206, Q8N6A6, Q8NFG7, Q96QQ9
      UniProtKB/TrEMBL
      Q8NFD3
      Conserved Domains (1) summary
      pfam00777
      Location:87 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_047427420.1 → XP_047283376.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X2

      UniProtKB/TrEMBL
      Q6IBE6, Q8NFD3

    8. XM_047427422.1 → XP_047283378.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X4

      UniProtKB/TrEMBL
      Q8NFD3

    9. XM_047427424.1 → XP_047283380.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X6

      UniProtKB/TrEMBL
      Q8NFD3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      126387091..126446076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369661.1 → XP_054225636.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X8

      UniProtKB/TrEMBL
      Q8NFD3

    2. XM_054369660.1 → XP_054225635.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X7

      UniProtKB/TrEMBL
      Q8NFD3

    3. XM_054369658.1 → XP_054225633.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X5

      UniProtKB/TrEMBL
      A0A7P0RGI5, Q8NFD3

    4. XM_054369656.1 → XP_054225631.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X3

      UniProtKB/TrEMBL
      Q8NFD3

    5. XM_054369654.1 → XP_054225629.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      A8K6B2, O60497, Q11206, Q8N6A6, Q8NFG7, Q96QQ9
      UniProtKB/TrEMBL
      Q8NFD3

    6. XM_054369653.1 → XP_054225628.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      A8K6B2, O60497, Q11206, Q8N6A6, Q8NFG7, Q96QQ9
      UniProtKB/TrEMBL
      Q8NFD3

    7. XM_054369655.1 → XP_054225630.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X2

      UniProtKB/TrEMBL
      Q6IBE6, Q8NFD3

    8. XM_054369659.1 → XP_054225634.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X6

      UniProtKB/TrEMBL
      Q8NFD3

    9. XM_054369657.1 → XP_054225632.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X4

      UniProtKB/TrEMBL
      Q8NFD3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11206.1 GenPept UniProtKB/Swiss-Prot:Q11206

    Gene LinkOut

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