Echdc3 enoyl CoA hydratase domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Echdc3provided by RGD
Official Full Name: enoyl CoA hydratase domain containing 3provided by RGD
Primary source: RGD:1589147
See related: EnsemblRapid:ENSRNOG00000048114 AllianceGenome:RGD:1589147
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables enoyl-CoA hydratase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Orthologous to human ECHDC3 (enoyl-CoA hydratase domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 388.6), Adrenal (RPKM 214.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (76980112..77002934)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (72070697..72093519)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (76002304..76022813)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enoyl-CoA hydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydro-lyase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: enoyl-CoA hydratase domain-containing protein 3, mitochondrial

Names: enoyl Coenzyme A hydratase domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101010.2 → NP_001094480.2 enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q3MIE0

UniProtKB/TrEMBL

A0A0G2JY01

Related

ENSRNOP00000070466.2, ENSRNOT00000086701.3

Conserved Domains (1) summary

cl23717
Location:35 → 299

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...