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    Atpaf2 ATP synthase mitochondrial F1 complex assembly factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atpaf2provided by RGD
    Official Full Name
    ATP synthase mitochondrial F1 complex assembly factor 2provided by RGD
    Primary source
    RGD:1305161
    See related
    EnsemblRapid:ENSRNOG00000003719 AllianceGenome:RGD:1305161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in cytosol and nuclear speck. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 1. Orthologous to human ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 140.2), Heart (RPKM 131.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atpaf2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45705157..45721282, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45205658..45221891, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46768539..46783889, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene retinoic acid induced 1 Neighboring gene sterol regulatory element binding transcription factor 1 Neighboring gene target of myb1 like 2 membrane trafficking protein Neighboring gene dynein regulatory complex subunit 3 Neighboring gene GID complex subunit 4 Neighboring gene ribosomal protein S4, X-linked, pseudogene 6 Neighboring gene developmentally regulated GTP binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase mitochondrial F1 complex assembly factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107006.1 → NP_001100476.1  ATP synthase mitochondrial F1 complex assembly factor 2

      See identical proteins and their annotated locations for NP_001100476.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6A7S3, A6HF39, D3ZTW7
      Related
      ENSRNOP00000004948.5, ENSRNOT00000004948.7
      Conserved Domains (1) summary
      pfam07542
      Location:57 → 177
      ATP12; ATP12 chaperone protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45705157..45721282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085956.2 → XP_038941884.1  ATP synthase mitochondrial F1 complex assembly factor 2 isoform X1

      Conserved Domains (1) summary
      cl02228
      Location:47 → 206
      ATP12; ATP12 chaperone protein

    2. XM_039085961.2 → XP_038941889.1  ATP synthase mitochondrial F1 complex assembly factor 2 isoform X3

      UniProtKB/TrEMBL
      A6HF41
      Conserved Domains (1) summary
      cl02228
      Location:1 → 163
      ATP12; ATP12 chaperone protein

    3. XM_063269007.1 → XP_063125077.1  ATP synthase mitochondrial F1 complex assembly factor 2 isoform X3

      UniProtKB/TrEMBL
      A6HF41

    4. XM_063269006.1 → XP_063125076.1  ATP synthase mitochondrial F1 complex assembly factor 2 isoform X2

    5. XM_039085960.2 → XP_038941888.1  ATP synthase mitochondrial F1 complex assembly factor 2 isoform X3

      UniProtKB/TrEMBL
      A6HF41
      Conserved Domains (1) summary
      cl02228
      Location:1 → 163
      ATP12; ATP12 chaperone protein

    6. XM_039085962.2 → XP_038941890.1  ATP synthase mitochondrial F1 complex assembly factor 2 isoform X4

      UniProtKB/TrEMBL
      A6HF42
      Conserved Domains (1) summary
      pfam07542
      Location:57 → 149
      ATP12; ATP12 chaperone protein

    RNA

    1. XR_005489811.2 RNA Sequence

      Related
      ENSRNOT00000116769.2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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