PLA1A phospholipase A1 member A [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLA1Aprovided by HGNC
Official Full Name: phospholipase A1 member Aprovided by HGNC
Primary source: HGNC:HGNC:17661
See related: Ensembl:ENSG00000144837 MIM:607460; AllianceGenome:HGNC:17661
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PSPLA1; PS-PLA1
Summary: The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Expression: Broad expression in liver (RPKM 8.5), lymph node (RPKM 6.1) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q13.33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (119597885..119629811)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (122317610..122349514)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (119316732..119348658)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidylserine-Specific Phospholipase A1 Limits Aggressiveness of Lung Adenocarcinoma by Lysophosphatidylserine and Protein Kinase A-Dependent Pathway.
Title: Phosphatidylserine-Specific Phospholipase A1 Limits Aggressiveness of Lung Adenocarcinoma by Lysophosphatidylserine and Protein Kinase A-Dependent Pathway.
Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis.
Title: Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis.
PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer.
Title: PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer.
Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma.
Title: Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma.
Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism.
Title: Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism.
Serum PS-PLA1 is associated with disease activity of systemic lupus erythematosus, indicating its possible use as a biomarker for monitoring SLE disease activity.
Title: Serum phosphatidylserine-specific phospholipase A(1) as a novel biomarker for monitoring systemic lupus erythematosus disease activity.
PLA1A interacts with hepatitis C virus E2, NS2 and NS5A via multiple interaction sites, which is important for HCV assembly
Title: Phosphatidylserine-Specific Phospholipase A1 is the Critical Bridge for Hepatitis C Virus Assembly.
this report identified PLA1A as a host factor that modulates the TBK1 activation during antiviral innate immune response
Title: PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.
Serum PS-PLA1 levels were significantly higher in the melanoma subjects and associated with the clinical stages.
Title: Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma.
the LysoPA levels might be determined largely by LysoPC and LysoPI (possible precursors) and the PS-PLA1-mediated pathway might be involved in the production of LysoPS in gastric cancer.
Title: Analysis of glycero-lysophospholipids in gastric cancerous ascites.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of phospholipase A1 member A (PLA1A) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of phospholipase A1 member A (PLA1A) in primary human brain microvascular endothelial cells	PubMed
	tat	HIV-1 Tat upregulates phospholipase A1 member A (PLA1A) expression in Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77236 (e-PCR)
- UniSTS:34308

STS-T96131 (e-PCR)
- UniSTS:69743

G29240 (e-PCR)
- UniSTS:32156

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatidylserine 1-acylhydrolase activity	TAS Traceable Author Statement more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylserine acyl-chain remodeling	TAS Traceable Author Statement more info
involved_in phosphatidylserine metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phospholipase A1 member A

Names: phosphatidylserine-specific phospholipase A1alpha

NP_001193889.1

EC 3.1.1.111

NP_001193890.1

EC 3.1.1.111

NP_001280154.1

EC 3.1.1.111

NP_056984.1

EC 3.1.1.111

XP_016862061.1

EC 3.1.1.111

XP_054202750.1

EC 3.1.1.111

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029696.1 RefSeqGene

Range

5011..36937

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001206960.2 → NP_001193889.1 phospholipase A1 member A isoform 2 precursor

See identical proteins and their annotated locations for NP_001193889.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

BC035347, BC047703, DB189568

Consensus CDS

CCDS56268.1

UniProtKB/Swiss-Prot

Q53H76

Related

ENSP00000417326.1, ENST00000495992.5

Conserved Domains (1) summary

pfam00151
Location:16 → 320

Lipase; Lipase
NM_001206961.2 → NP_001193890.1 phospholipase A1 member A isoform 3

See identical proteins and their annotated locations for NP_001193890.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. The resulting isoform (3) uses a downstream AUG start site and is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK301880, BC035347

Consensus CDS

CCDS56269.1

UniProtKB/Swiss-Prot

Q53H76

Related

ENSP00000420625.1, ENST00000488919.5

Conserved Domains (1) summary

cl21494
Location:2 → 159

Abhydrolase; alpha/beta hydrolases
NM_001293225.2 → NP_001280154.1 phospholipase A1 member A isoform 4

See identical proteins and their annotated locations for NP_001280154.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

BC035347, BX647516

Consensus CDS

CCDS77795.1

UniProtKB/TrEMBL

G5E9W0

Related

ENSP00000418793.1, ENST00000494440.5

Conserved Domains (2) summary

cd00707
Location:33 → 316

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

pfam00151
Location:10 → 320

Lipase; Lipase
NM_015900.4 → NP_056984.1 phospholipase A1 member A isoform 1 precursor

See identical proteins and their annotated locations for NP_056984.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK313519, BC035347

Consensus CDS

CCDS2991.1

UniProtKB/Swiss-Prot

B2R8V2, B4DXA2, O95991, Q53H76, Q86WX6, Q9UPD2

Related

ENSP00000273371.4, ENST00000273371.9

Conserved Domains (2) summary

cd00707
Location:49 → 332

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

pfam00151
Location:16 → 336

Lipase; Lipase

RNA

NR_120610.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF035269, BC035347, DB189568

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

119597885..119629811

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017006572.2 → XP_016862061.1 phospholipase A1 member A isoform X1

UniProtKB/Swiss-Prot

Q53H76

Conserved Domains (1) summary

cl21494
Location:2 → 159

Abhydrolase; alpha/beta hydrolases