Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3r5provided by MGI
Official Full Name: phosphoinositide-3-kinase regulatory subunit 5provided by MGI
Primary source: MGI:MGI:2443588
See related: Ensembl:ENSMUSG00000020901 AllianceGenome:MGI:2443588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p101; Foap2; F730038I15Rik
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity and G-protein beta/gamma-subunit complex binding activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; phosphatidylinositol metabolic process; and positive regulation of intracellular signal transduction. Predicted to be located in centriolar satellite; cytosol; and membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Is expressed in brain and retina nuclear layer. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 27.4), spleen adult (RPKM 14.3) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 41.69 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (68322951..68388675)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (68432125..68497849)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
Title: lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5.
Title: Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5.
Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils.
Title: Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-3-kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables G-protein beta/gamma-subunit complex binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IB	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoinositide 3-kinase regulatory subunit 5

Names: PI3-kinase p101 subunit; PI3-kinase regulatory subunit 5; p101-PI3K; phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; phosphoinositide-3-kinase, regulatory subunit 5, p101; ptdIns-3-kinase p101; ptdIns-3-kinase regulatory subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177320.2 → NP_796294.2 phosphoinositide 3-kinase regulatory subunit 5

See identical proteins and their annotated locations for NP_796294.2

Status: VALIDATED

Source sequence(s)

AK089483, AK149847, AL606831

Consensus CDS

CCDS24865.1

UniProtKB/Swiss-Prot

Q3TU01, Q3UDZ2, Q5SW28, Q8C215, Q8CGQ7

UniProtKB/TrEMBL

A1A4T4

Related

ENSMUSP00000021283.8, ENSMUST00000021283.8

Conserved Domains (1) summary

pfam10486
Location:6 → 871

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

68322951..68388675

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533548.3 → XP_006533611.1 phosphoinositide 3-kinase regulatory subunit 5 isoform X1

See identical proteins and their annotated locations for XP_006533611.1

UniProtKB/Swiss-Prot

Q3TU01, Q3UDZ2, Q5SW28, Q8C215, Q8CGQ7

UniProtKB/TrEMBL

A1A4T4

Conserved Domains (1) summary

pfam10486
Location:6 → 871

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit