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    Mcrip2 MAPK regulated corepressor interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcrip2provided by MGI
    Official Full Name
    MAPK regulated corepressor interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1915491
    See related
    Ensembl:ENSMUSG00000025732 AllianceGenome:MGI:1915491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam195a; 9530058B02Rik
    Summary
    Predicted to be located in cytoplasmic stress granule and nucleus. Is expressed in adrenal gland and axial musculature. Orthologous to human MCRIP2 (MAPK regulated corepressor interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 430.7), ovary adult (RPKM 71.9) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcrip2 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.96 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26082672..26087738, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25863698..25868740, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member T2 Neighboring gene WD repeat domain 90 Neighboring gene STARR-positive B cell enhancer ABC_E10938 Neighboring gene nuclear encoded tRNA glycine 7 (anticodon CCC) Neighboring gene methyltransferase like 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A. Cannavino J, et al. Proc Natl Acad Sci U S A, 2021 Jun 8. PMID 34088848, Free PMC Article
    2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A.
      Title: Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MAPK regulated corepressor interacting protein 2
    Names
    family with sequence similarity 195, member A
    protein FAM195A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378771.1 → NP_001365700.1  MAPK regulated corepressor interacting protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Conserved Domains (1) summary
      pfam14799
      Location:61 → 173
      FAM195; FAM195 family

    2. NM_001378772.1 → NP_001365701.1  MAPK regulated corepressor interacting protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Conserved Domains (1) summary
      pfam14799
      Location:62 → 158
      FAM195; FAM195 family

    3. NM_026633.3 → NP_080909.1  MAPK regulated corepressor interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_080909.1

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Consensus CDS
      CCDS28535.1
      UniProtKB/Swiss-Prot
      Q9CQB2
      UniProtKB/TrEMBL
      A0A494B9S0
      Related
      ENSMUSP00000026828.6, ENSMUST00000026828.7
      Conserved Domains (1) summary
      pfam14799
      Location:61 → 154
      FAM195; FAM195 family

    RNA

    1. NR_166092.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159277

    2. NR_166093.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159277

    3. NR_166094.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159277

    4. NR_166095.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159277
      Related
      ENSMUST00000237080.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26082672..26087738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160758.1 → XP_036016651.1  MAPK regulated corepressor interacting protein 2 isoform X1

      Conserved Domains (1) summary
      pfam14799
      Location:62 → 174
      FAM195; FAM195 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQB2.1 GenPept UniProtKB/Swiss-Prot:Q9CQB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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