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    Tnfaip8 TNF alpha induced protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307428, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnfaip8provided by RGD
    Official Full Name
    TNF alpha induced protein 8provided by RGD
    Primary source
    RGD:1305908
    See related
    EnsemblRapid:ENSRNOG00000026136 AllianceGenome:RGD:1305908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; molecular sequestering activity; and small molecule binding activity. Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within defense response to Gram-positive bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human TNFAIP8 (TNF alpha induced protein 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 129.3), Thymus (RPKM 124.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Tnfaip8 in Genome Data Viewer
    Location:
    18q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (45370334..45486036)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (43183854..43299512)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (44664310..44779914)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene Dmx-like 1 Neighboring gene uncharacterized LOC120098294 Neighboring gene uncharacterized LOC120098293 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 4 Neighboring gene uncharacterized LOC120098292 Neighboring gene family with sequence similarity 170, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    tumor necrosis factor alpha-induced protein 8
    Names
    tumor necrosis factor, alpha-induced protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107387.2NP_001100857.2  tumor necrosis factor alpha-induced protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6IX01, D4A9G3
      Related
      ENSRNOP00000021972.4, ENSRNOT00000021972.7
      Conserved Domains (1) summary
      pfam05527
      Location:51205
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      45370334..45486036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254709.5XP_006254771.1  tumor necrosis factor alpha-induced protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y0F2
      Related
      ENSRNOP00000076830.1, ENSRNOT00000118975.2
      Conserved Domains (1) summary
      pfam05527
      Location:27181
      DUF758; Domain of unknown function (DUF758)
    2. XM_039096838.2XP_038952766.1  tumor necrosis factor alpha-induced protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2P3
      Related
      ENSRNOP00000072322.2, ENSRNOT00000086431.3
      Conserved Domains (1) summary
      pfam05527
      Location:37191
      DUF758; Domain of unknown function (DUF758)
    3. XM_006254708.5XP_006254770.1  tumor necrosis factor alpha-induced protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AJX1
      Related
      ENSRNOP00000108196.1, ENSRNOT00000140138.1
      Conserved Domains (1) summary
      pfam05527
      Location:31185
      DUF758; Domain of unknown function (DUF758)
    4. XM_063277358.1XP_063133428.1  tumor necrosis factor alpha-induced protein 8 isoform X4

      UniProtKB/TrEMBL
      A6IX03
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