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    Myh2 myosin heavy chain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691644, updated on 27-Dec-2024

    Summary

    Official Symbol
    Myh2provided by RGD
    Official Full Name
    myosin heavy chain 2provided by RGD
    Primary source
    RGD:620354
    See related
    EnsemblRapid:ENSRNOG00000065740 AllianceGenome:RGD:620354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Myh1; Myh2a; MyHC-2A; MyHC-IIA
    Summary
    Predicted to enable several functions, including ATP binding activity; actin filament binding activity; and calmodulin binding activity. Predicted to be involved in muscle contraction. Predicted to act upstream of or within actin-mediated cell contraction; plasma membrane repair; and response to muscle activity. Predicted to be located in several cellular components, including A band; Golgi apparatus; and actomyosin contractile ring. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in congenital myopathy 6 and inclusion body myositis. Orthologous to human MYH2 (myosin heavy chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 24451.0) See more
    Orthologs
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    Genomic context

    See Myh2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52355739..52382235)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (51856738..51883236)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53711895..53738164)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693350 Neighboring gene uncharacterized LOC134480700 Neighboring gene uncharacterized LOC102555216 Neighboring gene myosin heavy chain 1 Neighboring gene myosin heavy chain 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables actin filament binding  
    enables calmodulin binding  
    enables cytoskeletal motor activity  
    Component Evidence Code Pubs
    located_in A band  
    located_in Golgi apparatus  
    located_in actomyosin contractile ring  
    located_in cell-cell junction  
    located_in myofibril  
    part_of myosin complex  
    located_in myosin filament  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    myosin-2
    Names
    2A myosin heavy chain
    myosin heavy chain IIa
    myosin heavy chain type IIx
    myosin, heavy chain 2, skeletal muscle, adult
    myosin, heavy polypeptide 2, skeletal muscle, adult

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135157.1NP_001128629.1  myosin-2

      See identical proteins and their annotated locations for NP_001128629.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K0F5, A6HFI0, G3V6E1
      Related
      ENSRNOP00000004236.7, ENSRNOT00000004236.8
      Conserved Domains (3) summary
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3573
      Myosin_N; Myosin N-terminal SH3-like domain
      cl22853
      Location:100773
      Motor_domain; Myosin and Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      52355739..52382235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086900.2XP_038942828.1  myosin-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0F5, A6HFI0, G3V6E1
      Conserved Domains (3) summary
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3573
      Myosin_N; Myosin N-terminal SH3-like domain
      cl22853
      Location:100773
      Motor_domain; Myosin and Kinesin motor domain
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