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    Slc17a7 solute carrier family 17 member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116638, updated on 4-Jan-2025

    Summary

    Official Symbol
    Slc17a7provided by RGD
    Official Full Name
    solute carrier family 17 member 7provided by RGD
    Primary source
    RGD:620101
    See related
    EnsemblRapid:ENSRNOG00000020650 AllianceGenome:RGD:620101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BNPI; Vglut1
    Summary
    Enables chloride channel activity and secondary active transmembrane transporter activity. Involved in several processes, including L-glutamate transmembrane transport; regulation of synaptic vesicle endocytosis; and sodium-dependent phosphate transport. Located in excitatory synapse and presynaptic active zone. Is active in synaptic vesicle membrane. Biomarker of sciatic neuropathy and transient cerebral ischemia. Orthologous to human SLC17A7 (solute carrier family 17 member 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 1407.7) See more
    Orthologs
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    Genomic context

    See Slc17a7 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104786172..104798049)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95649709..95661591)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101161265..101172292)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Fms related receptor tyrosine kinase 3 ligand Neighboring gene aldehyde dehydrogenase 16 family, member A1 Neighboring gene PIH1 domain containing 1 Neighboring gene golgi-associated, olfactory signaling regulator Neighboring gene parathyroid hormone 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 29
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-glutamate import  
    involved_in L-glutamate transmembrane transport PubMed 
    involved_in L-glutamate transmembrane transport  
    acts_upstream_of_or_within chemical synaptic transmission  
    involved_in chloride transmembrane transport  
    involved_in chloride transport PubMed 
    acts_upstream_of_or_within establishment of localization in cell  
    acts_upstream_of_or_within excitatory postsynaptic potential  
    acts_upstream_of_or_within long-term memory  
    acts_upstream_of_or_within maintenance of location in cell  
    involved_in neural retina development PubMed 
    involved_in neurotransmitter loading into synaptic vesicle  
    involved_in neurotransmitter loading into synaptic vesicle  
    involved_in phosphate ion homeostasis PubMed 
    involved_in phosphate ion homeostasis  
    involved_in phosphate ion transmembrane transport  
    involved_in phosphate ion transport PubMed 
    involved_in phosphate ion transport  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transport PubMed 
    involved_in regulation of synapse structure or activity  
    involved_in regulation of synaptic vesicle endocytosis PubMed 
    acts_upstream_of_or_within sequestering of neurotransmitter  
    involved_in sodium ion transmembrane transport  
    involved_in sodium-dependent phosphate transport PubMed 
    involved_in sodium-dependent phosphate transport  
    involved_in synaptic transmission, glutamatergic  
    acts_upstream_of_or_within synaptic transmission, glutamatergic  
    acts_upstream_of_or_within synaptic vesicle lumen acidification  
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in cerebellar mossy fiber  
    part_of chloride channel complex  
    is_active_in excitatory synapse  
    located_in excitatory synapse PubMed 
    located_in excitatory synapse  
    located_in membrane  
    located_in plasma membrane  
    located_in postsynapse  
    located_in presynaptic active zone PubMed 
    located_in presynaptic active zone  
    located_in synapse PubMed 
    located_in synapse  
    located_in synaptic vesicle  
    is_active_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    vesicular glutamate transporter 1
    Names
    brain-specific Na(+)-dependent inorganic phosphate cotransporter
    brain-specific Na-dependent inorganic phosphate cotransporter
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
    solute carrier family 17 (vesicular glutamate transporter), member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053859.5NP_446311.1  vesicular glutamate transporter 1

      See identical proteins and their annotated locations for NP_446311.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      A9LRT0, Q62634
      UniProtKB/TrEMBL
      A6JAY9, A6JAZ0
      Related
      ENSRNOP00000099148.1, ENSRNOT00000151521.1
      Conserved Domains (1) summary
      cd17382
      Location:66490
      MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104786172..104798049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110953.2XP_038966881.1  vesicular glutamate transporter 1 isoform X1

      UniProtKB/TrEMBL
      A6JAY9
      Related
      ENSRNOP00000063604.1, ENSRNOT00000064184.6
      Conserved Domains (1) summary
      cd17382
      Location:66515
      MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters
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