U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    BAZ1A bromodomain adjacent to zinc finger domain 1A [ Homo sapiens (human) ]

    Gene ID: 11177, updated on 4-Jan-2025

    Summary

    Official Symbol
    BAZ1Aprovided by HGNC
    Official Full Name
    bromodomain adjacent to zinc finger domain 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:960
    See related
    Ensembl:ENSG00000198604 MIM:605680; AllianceGenome:HGNC:960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACF1; WALp1; hACF1; WCRF180
    Summary
    The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010]
    Expression
    Broad expression in testis (RPKM 18.1), bone marrow (RPKM 15.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BAZ1A in Genome Data Viewer
    Location:
    14q13.1-q13.2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (34752731..34875360, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (28951901..29074526, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35221937..35344566, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5668 Neighboring gene Sharpr-MPRA regulatory region 5589 Neighboring gene cofilin 2 Neighboring gene ribosomal protein L12 pseudogene 6 Neighboring gene MPRA-validated peak2136 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr14:35306879-35307380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:35312782-35313282 Neighboring gene RNA, U7 small nuclear 41 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5672 Neighboring gene BAZ1A antisense RNA 1 Neighboring gene SRP54 antisense RNA 1 Neighboring gene IGBP1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 9881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:35451517-35452218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8259 Neighboring gene signal recognition particle 54

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of bromodomain adjacent to zinc finger domain, 1A (BAZ1A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ14383, DKFZp586E0518

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    NOT enables histone acetyltransferase activity PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of ACF complex PubMed 
    part_of ACF complex PubMed 
    part_of CHRAC  
    part_of CHRAC PubMed 
    part_of CHRAC PubMed 
    is_active_in nuclear chromosome  
    located_in nucleus PubMed 
    located_in pericentric heterochromatin PubMed 
    located_in pericentric heterochromatin  

    General protein information

    Preferred Names
    bromodomain adjacent to zinc finger domain protein 1A
    Names
    ATP-dependent chromatin remodeling protein
    ATP-utilizing chromatin assembly and remodeling factor 1
    CHRAC subunit ACF1
    hWALp1
    williams syndrome transcription factor-related chromatin-remodeling factor 180

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013448.3 → NP_038476.2  bromodomain adjacent to zinc finger domain protein 1A isoform a

      See identical proteins and their annotated locations for NP_038476.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB032252, AF213467, AF221130, AL050089, CB217757
      Consensus CDS
      CCDS9651.1
      UniProtKB/Swiss-Prot
      Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3
      Related
      ENSP00000353458.1, ENST00000360310.6
      Conserved Domains (7) summary
      cd05504
      Location:1423 → 1535
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      smart00571
      Location:422 → 485
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1150 → 1195
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:590 → 635
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:800 → 926
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl26511
      Location:645 → 788
      Neuromodulin_N; Gap junction protein N-terminal region
    2. NM_182648.2 → NP_872589.1  bromodomain adjacent to zinc finger domain protein 1A isoform b

      See identical proteins and their annotated locations for NP_872589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB032252, AF213467, AF221130, AL050089, CB217757
      Consensus CDS
      CCDS41943.1
      Related
      ENSP00000351555.4, ENST00000358716.8
      Conserved Domains (8) summary
      cd05504
      Location:1391 → 1503
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      smart00571
      Location:422 → 485
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1118 → 1163
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilizing chromatin assembly and remodelling N-terminal
      pfam15612
      Location:560 → 608
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15614
      Location:860 → 898
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:682 → 693
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:617 → 695
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      34752731..34875360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430887.1 → XP_047286843.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

    2. XM_024449460.2 → XP_024305228.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

      UniProtKB/Swiss-Prot
      Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3
      Conserved Domains (7) summary
      cd05504
      Location:1423 → 1535
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      smart00571
      Location:422 → 485
      DDT; domain in different transcription and chromosome remodeling factors
      cd15627
      Location:1150 → 1195
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam10537
      Location:23 → 122
      WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
      pfam15612
      Location:590 → 635
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:800 → 926
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl26511
      Location:645 → 788
      Neuromodulin_N; Gap junction protein N-terminal region
    3. XM_047430889.1 → XP_047286845.1  bromodomain adjacent to zinc finger domain protein 1A isoform X4

    4. XM_047430888.1 → XP_047286844.1  bromodomain adjacent to zinc finger domain protein 1A isoform X3

    5. XM_011536376.4 → XP_011534678.3  bromodomain adjacent to zinc finger domain protein 1A isoform X5

      UniProtKB/TrEMBL
      Q59G54
      Conserved Domains (5) summary
      cd05504
      Location:1019 → 1131
      Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
      cd15627
      Location:746 → 791
      PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
      pfam15612
      Location:186 → 231
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      pfam15613
      Location:396 → 522
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl26511
      Location:241 → 384
      Neuromodulin_N; Gap junction protein N-terminal region

    RNA

    1. XR_007063978.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      28951901..29074526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375297.1 → XP_054231272.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

    2. XM_054375296.1 → XP_054231271.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

      UniProtKB/Swiss-Prot
      Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3
    3. XM_054375299.1 → XP_054231274.1  bromodomain adjacent to zinc finger domain protein 1A isoform X4

    4. XM_054375298.1 → XP_054231273.1  bromodomain adjacent to zinc finger domain protein 1A isoform X3

    5. XM_054375300.1 → XP_054231275.1  bromodomain adjacent to zinc finger domain protein 1A isoform X5

      UniProtKB/TrEMBL
      Q59G54

    RNA

    1. XR_008488815.1 RNA Sequence

    Loading
    External link. Please review our privacy policy.