Hapstr1 HUWE1 associated protein modifying stress responses [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hapstr1provided by RGD
Official Full Name: HUWE1 associated protein modifying stress responsesprovided by RGD
Primary source: RGD:1309748
See related: EnsemblRapid:ENSRNOG00000002545 AllianceGenome:RGD:1309748
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309748
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of signal transduction by p53 class mediator and regulation of cellular response to stress. Predicted to be located in cytoplasm and nucleus. Orthologous to human HAPSTR1 (HUWE1 associated protein modifying stress responses). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 261.8), Testes (RPKM 222.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (7252737..7281678, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (6746037..6774992, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (6841071..6870011, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA792997 (e-PCR)
- UniSTS:160520

NoName (e-PCR)
- UniSTS:492113

C160rf72 (e-PCR)
- UniSTS:519358

AI548550 (e-PCR)
- UniSTS:226250

RH130190 (e-PCR)
- UniSTS:213477

RH131219 (e-PCR)
- UniSTS:214502

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: HUWE1-associated protein modifying stress responses 1

Names: UPF0472 protein C16orf72 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.