U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ufl1 UFM1 specific ligase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40843, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ufl1provided by FlyBase
    Official Full Name
    UFM1 specific ligase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037467
    Locus tag
    Dmel_CG1104
    See related
    AllianceGenome:FB:FBgn0037467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1104; Dmel\CG1104; UFL1
    Summary
    Enables UFM1 ligase activity. Involved in protein ufmylation. Located in endomembrane system. Is expressed in several structures, including adult head; dorsal epidermis primordium; embryonic dorsal epidermis; embryonic ventral epidermis; and gland. Orthologous to human UFL1 (UFM1 specific ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ufl1 in Genome Data Viewer
    Location:
    84B2-84B2; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7071624..7074452, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2897346..2900174, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Male-specific transcript 84B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45908 Neighboring gene uncharacterized protein Neighboring gene RNA and export factor binding protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The UFM1 cascade times mitosis entry associated with microcephaly. Yu L, et al. FASEB J, 2020 Jan. PMID 31914610
    2. UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia. Duan R, et al. PLoS One, 2016. PMID 26872069, Free PMC Article
    3. A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila. Li H, et al. Cell Mol Life Sci, 2023 Apr 22. PMID 37086384, Free PMC Article
    4. Mapping organelle proteins and protein complexes in Drosophila melanogaster. Tan DJ, et al. J Proteome Res, 2009 Jun. PMID 19317464
    5. A Luciferase-fragment Complementation Assay to Detect Lipid Droplet-associated Protein-Protein Interactions. Kolkhof P, et al. Mol Cell Proteomics, 2017 Mar. PMID 27956707, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UFM1 ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UFM1 ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables UFM1 ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables UFM1 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ufmylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ufmylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ufmylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    UFM1 specific ligase 1
    Names
    CG1104-PA
    CG1104-PC
    Ufl1-PA
    Ufl1-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7071624..7074452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260028.2 → NP_001246957.1  UFM1 specific ligase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8INS2, Q9VI55
      UniProtKB/TrEMBL
      A0A0B4K6K7
      Conserved Domains (1) summary
      pfam09743
      Location:7 → 271
      DUF2042; Uncharacterized conserved protein (DUF2042)

    2. NM_141433.3 → NP_649690.1  UFM1 specific ligase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649690.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8INS2, Q9VI55
      UniProtKB/TrEMBL
      A0A0B4K6K7
      Related
      FBpp0081157
      Conserved Domains (1) summary
      pfam09743
      Location:7 → 271
      DUF2042; Uncharacterized conserved protein (DUF2042)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6K7 A0A0B4K6K7
    Q9VI55.1 Q9VI55

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous