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    corolla corolla [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32739, updated on 17-Dec-2024

    Summary

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    Official Symbol
    corollaprovided by FlyBase
    Official Full Name
    corollaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267967
    Locus tag
    Dmel_CG8316
    See related
    AllianceGenome:FB:FBgn0267967
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8316; Corolla; Dmel\CG8316; mei-39
    Summary
    Enables protein phosphatase 1 binding activity. Involved in centromere clustering and meiotic nuclear division. Located in synaptonemal complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See corolla in Genome Data Viewer
    Location:
    16B10-16B10; 1-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17629791..17632047, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17523824..17526080, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Stasimon Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 24 kDa subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synaptonemal Complex-Deficient Drosophila melanogaster Females Exhibit Rare DSB Repair Events, Recurrent Copy-Number Variation, and an Increased Rate of de Novo Transposable Element Movement. Miller DE. G3 (Bethesda), 2020 Feb 6. PMID 31882405, Free PMC Article
    2. Genetic background impacts the timing of synaptonemal complex breakdown in Drosophila melanogaster. Wesley ER, et al. Chromosoma, 2020 Dec. PMID 33068154, Free PMC Article
    3. Unconventional conservation reveals structure-function relationships in the synaptonemal complex. Kursel LE, et al. Elife, 2021 Nov 17. PMID 34787570, Free PMC Article
    4. Corolla is a novel protein that contributes to the architecture of the synaptonemal complex of Drosophila. Collins KA, et al. Genetics, 2014 Sep. PMID 24913682, Free PMC Article
    5. The Drosophila CPEB Protein Orb Specifies Oocyte Fate by a 3'UTR-Dependent Autoregulatory Loop. Barr J, et al. Genetics, 2019 Dec. PMID 31594794, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centromere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break processing involved in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    corolla
    Names
    CG8316-PA
    CG8316-PB
    corolla-PA
    corolla-PB
    meiotic 39

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17629791..17632047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298448.1 → NP_001285377.1  corolla, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JKX2
      Conserved Domains (1) summary
      pfam15921
      Location:12 → 268
      CCDC158; Coiled-coil domain-containing protein 158

    2. NM_132999.3 → NP_573227.1  corolla, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RR4, Q9VX37
      Related
      FBpp0074259
      Conserved Domains (1) summary
      TIGR00570
      Location:102 → 222
      cdk7; CDK-activating kinase assembly factor MAT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX37 Q9VX37
    X2JKX2 X2JKX2

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