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    Not3 CCR4-NOT transcription complex subunit 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35501, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Not3provided by FlyBase
    Official Full Name
    CCR4-NOT transcription complex subunit 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0033029
    Locus tag
    Dmel_CG8426
    See related
    AllianceGenome:FB:FBgn0033029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8426; CNOT3; Dmel\CG8426; dNot3; l(2)Nc136; l(2)NC136; not3; NOT3; NOT3.5; NOT3/5
    Summary
    Involved in negative regulation of translation and nuclear-transcribed mRNA poly(A) tail shortening. Located in cytosol. Part of CCR4-NOT complex. Is expressed in adult head; pole plasm; and primordial germ cell. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Not3 in Genome Data Viewer
    Location:
    41F6-41F6; 2-55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5656406..5663222, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1543911..1550727, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hermes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45472 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs. Arvola RM, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31863588, Free PMC Article
    2. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. De Keersmaecker K, et al. Nat Genet, 2013 Feb. PMID 23263491, Free PMC Article
    3. Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets. Sgromo A, et al. RNA, 2018 Mar. PMID 29255063, Free PMC Article
    4. In Vitro Reconstitution of the Drosophila melanogaster CCR4-NOT Complex to Assay Deadenylation. Pekovic F, et al. Methods Mol Biol, 2024. PMID 37824062
    5. The Bic-C family of developmental translational regulators. Gamberi C, et al. Comp Funct Genomics, 2012. PMID 22611335, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 3
    Names
    CG8426-PA
    CG8426-PB
    Not3-PA
    Not3-PB
    lethal (2) NC136
    lethal(2)NC136

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5656406..5663222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273783.1 → NP_001260712.1  CCR4-NOT transcription complex subunit 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K126
      Conserved Domains (3) summary
      pfam04065
      Location:3 → 233
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:711 → 836
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
      pfam12446
      Location:428 → 509
      DUF3682; Protein of unknown function (DUF3682)

    2. NM_136332.3 → NP_610176.1  CCR4-NOT transcription complex subunit 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K126
      Related
      FBpp0085398
      Conserved Domains (3) summary
      pfam04065
      Location:3 → 233
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:711 → 836
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
      pfam12446
      Location:428 → 509
      DUF3682; Protein of unknown function (DUF3682)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K126 Q7K126

    Gene LinkOut

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