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    santa-maria scavenger receptor acting in neural tissue and majority of rhodopsin is absent [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34024, updated on 9-Dec-2024

    Summary

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    Official Symbol
    santa-mariaprovided by FlyBase
    Official Full Name
    scavenger receptor acting in neural tissue and majority of rhodopsin is absentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025697
    Locus tag
    Dmel_CG12789
    See related
    AllianceGenome:FB:FBgn0025697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK01577; CG12789; CK01577; Dmel\CG12789; santa maria; Santa Maria
    Summary
    Predicted to enable scavenger receptor activity. Involved in several processes, including phototransduction; rhodopsin biosynthetic process; and thermotaxis. Predicted to be active in membrane. Is expressed in several structures, including Bolwig organ; adult head; amnioserosa; embryonic central brain neurons; and embryonic head epidermis. Used to study sensorineural hearing loss. Orthologous to human SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See santa-maria in Genome Data Viewer
    Location:
    28A1-28A1; 2-27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7445355..7451244, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7445355..7451244, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene midline uncoordinated Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 28a Neighboring gene Gustatory receptor 28b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanisms of vitamin A metabolism and deficiency in the mammalian and fly visual system. Dewett D, et al. Dev Biol, 2021 Aug. PMID 33774009, Free PMC Article
    2. Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2. Guntur AR, et al. Proc Natl Acad Sci U S A, 2015 Oct 20. PMID 26443856, Free PMC Article
    3. Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types. Yeung K, et al. Commun Biol, 2022 Dec 14. PMID 36517671, Free PMC Article
    4. Retinoids regulate a developmental checkpoint for tissue regeneration in Drosophila. Halme A, et al. Curr Biol, 2010 Mar 9. PMID 20189388, Free PMC Article
    5. Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium. Dong Z, et al. BMC Biol, 2023 Jun 20. PMID 37340484, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carotenoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor acting in neural tissue and majority of rhodopsin is absent
    Names
    CG12789-PA
    CG12789-PC
    SANTA-MARIA
    santa maria
    santa-maria-PA
    santa-maria-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7445355..7451244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164752.4 → NP_723277.3  scavenger receptor acting in neural tissue and majority of rhodopsin is absent, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723277.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPI3, Q9VM10
      Related
      FBpp0079088
      Conserved Domains (1) summary
      pfam01130
      Location:23 → 474
      CD36; CD36 family

    2. NM_135277.3 → NP_609121.2  scavenger receptor acting in neural tissue and majority of rhodopsin is absent, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609121.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPI3, Q9VM10
      Conserved Domains (1) summary
      pfam01130
      Location:23 → 474
      CD36; CD36 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961H6 Q961H6
    Q9VM10 Q9VM10

    Gene LinkOut

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