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    side-VII sidestep VII [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    side-VIIprovided by FlyBase
    Official Full Name
    sidestep VIIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037736
    Locus tag
    Dmel_CG12950
    See related
    AllianceGenome:FB:FBgn0037736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12950; CG12950; CT32101; Dmel\CG12950
    Summary
    Enables cell adhesion receptor activity. Involved in synapse assembly. Is active in presynaptic membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval tracheal dorsal trunk; ganglia; and larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See side-VII in Genome Data Viewer
    Location:
    85E6-85E6; 3-49 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9734012..9739979, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5559734..5565701, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Forkhead box P Neighboring gene alpha-Tubulin at 85E Neighboring gene Pinin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Searching for guidance cues: follow the Sidestep trail. Aberle H. Fly (Austin), 2009 Oct-Dec. PMID 19786838
    2. Complex formation of immunoglobulin superfamily molecules Side-IV and Beat-IIb regulates synaptic specificity. Osaka J, et al. Cell Rep, 2024 Feb 27. PMID 38381608
    3. Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development. Li H, et al. Elife, 2017 Aug 15. PMID 28829740, Free PMC Article
    4. An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Özkan E, et al. Cell, 2013 Jul 3. PMID 23827685, Free PMC Article
    5. The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity. Vogel C, et al. Development, 2003 Dec. PMID 14623821

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sidestep VII
    Names
    CG12950-PA
    CG12950-PB
    side-VII-PA
    side-VII-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9734012..9739979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275503.1 → NP_001262432.1  sidestep VII, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262432.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0P8, Q9VH85
      Conserved Domains (7) summary
      smart00408
      Location:360 → 425
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:32 → 134
      IG_like; Immunoglobulin like
      cd00063
      Location:538 → 620
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07686
      Location:32 → 134
      V-set; Immunoglobulin V-set domain
      pfam13927
      Location:456 → 519
      Ig_3; Immunoglobulin domain
      pfam14851
      Location:643 → 741
      FAM176; FAM176 family
      cl11960
      Location:262 → 328
      Ig; Immunoglobulin domain

    2. NM_141676.3 → NP_649933.1  sidestep VII, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0P8, Q9VH85
      Related
      FBpp0081648
      Conserved Domains (7) summary
      smart00408
      Location:360 → 425
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:32 → 134
      IG_like; Immunoglobulin like
      cd00063
      Location:538 → 620
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07686
      Location:32 → 134
      V-set; Immunoglobulin V-set domain
      pfam13927
      Location:456 → 519
      Ig_3; Immunoglobulin domain
      pfam14851
      Location:643 → 741
      FAM176; FAM176 family
      cl11960
      Location:262 → 328
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH85 Q9VH85

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