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    Pgant3 Polypeptide N-Acetylgalactosaminyltransferase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgant3provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0027558
    Locus tag
    Dmel_CG4445
    See related
    AllianceGenome:FB:FBgn0027558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.119; BcDNA:GH09147; CG4445; Dmel\CG4445; pgant3; ppGalNAcT3
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in several processes, including O-glycan processing; extracellular matrix constituent secretion; and regulation of cell adhesion mediated by integrin. Located in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval midgut primordium; gut section; and imaginal disc. Orthologous to human GALNT3 (polypeptide N-acetylgalactosaminyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgant3 in Genome Data Viewer
    Location:
    42E7-42E7; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7057654..7061732, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2945159..2949237, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42En Neighboring gene Tetraspanin 42Ep Neighboring gene Tetraspanin 42Eo Neighboring gene Tetraspanin 42Eq Neighboring gene Tetraspanin 42Er

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two protein N-acetylgalactosaminyl transferases regulate synaptic plasticity by activity-dependent regulation of integrin signaling. Dani N, et al. J Neurosci, 2014 Sep 24. PMID 25253852, Free PMC Article
    2. The cellular microenvironment and cell adhesion: a role for O-glycosylation. Zhang L, et al. Biochem Soc Trans, 2011 Jan. PMID 21265808, Free PMC Article
    3. Mucin-Type O-Glycosylation in the Drosophila Nervous System. Itoh K, et al. Front Neuroanat, 2021. PMID 34733141, Free PMC Article
    4. O-glycosylation regulates polarized secretion by modulating Tango1 stability. Zhang L, et al. Proc Natl Acad Sci U S A, 2014 May 20. PMID 24799692, Free PMC Article
    5. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the glycosyltransferase, pgant3, specifically modulates integrin-mediated cell adhesion by influencing the secretion and localization of the integrin ligand, Tiggrin
      Title: An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in O-glycan processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 3
    Names
    CG4445-PA
    Pgant3-PA
    polypeptide GalNAc transferase 3
    NP_610256.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7057654..7061732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136412.4 → NP_610256.1  polypeptide N-Acetylgalactosaminyltransferase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610256.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9Y117
      Related
      FBpp0088130
      Conserved Domains (2) summary
      cd02510
      Location:153 → 457
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:516 → 658
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y117.1 Q9Y117

    Gene LinkOut

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