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    Hug Hugin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41547, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Hugprovided by FlyBase
    Official Full Name
    Huginprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028374
    Locus tag
    Dmel_CG6371
    See related
    AllianceGenome:FB:FBgn0028374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6371; Dmel\CG6371; Drm-MT2; Drm-PK-2; hug; HUG; hug gamma; hug-1; hug-2; hug-gamma; Hug-gamma; hug-PK; Hug-PK; hugg; huggamma; HUGgamma; hugin; Hugin PK; Hugin-PK-2; huginPK; PK-2; pyrokinin/PBAN-like
    Summary
    Enables myostimulatory hormone activity and neuropeptide receptor binding activity. Involved in ecdysis, chitin-based cuticle; larval feeding behavior; and neuropeptide signaling pathway. Located in extracellular space. Is expressed in several structures, including Hugin neurons; larval central nervous system; and larval gnathal ganglion. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Hug in Genome Data Viewer
    Location:
    87B15-87B15; 3-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12526188..12529076)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8351910..8354798)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Heat shock protein 70 Bc Neighboring gene Octopamine beta3 receptor Neighboring gene long non-coding RNA:CR46016 Neighboring gene Octopamine beta2 receptor Neighboring gene mir-284 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuromedin U and its putative Drosophila homolog hugin. Melcher C, et al. PLoS Biol, 2006 Mar. PMID 16524341, Free PMC Article
    2. Insect PRXamides: Evolutionary Divergence, Novelty, and Loss in a Conserved Neuropeptide System. Farris SM. J Insect Sci, 2023 Jan 1. PMID 36661324, Free PMC Article
    3. Single-cell peptidomics of drosophila melanogaster neurons identified by Gal4-driven fluorescence. Neupert S, et al. Anal Chem, 2007 May 15. PMID 17439240
    4. Making Feeding Decisions in the Drosophila Nervous System. Miroschnikow A, et al. Curr Biol, 2020 Jul 20. PMID 32693083
    5. Fraenkel's pupariation factor identified at last. Verleyen P, et al. Dev Biol, 2004 Sep 1. PMID 15302596

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hugin (+) neurons provide a link between sleep homeostat and circadian clock neurons.
      Title: Hugin(+) neurons provide a link between sleep homeostat and circadian clock neurons.
    2. The DH44 PI-Hugin SEZ circuit controls circadian locomotor activity in a daily cycle but has minimal effect on feeding rhythms, suggesting that the circadian drive to feed can be separated from circadian locomotion.
      Title: A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.
    3. Our study reveals novel complexity in the morphology of individual hugin neurons, which has functional implication for how they coordinate feeding behavior and growth.
      Title: Genetic dissection of neural circuit anatomy underlying feeding behavior in Drosophila: distinct classes of hugin-expressing neurons.
    4. Upon cDNA sequence analysis and in vitro expression assays, the hugin gene was found to encode a signal peptide containing proprotein that was further processed in Schneider-2 cells into peptides similar to known neuropeptides.
      Title: The Drosophila hugin gene codes for myostimulatory and ecdysis-modifying neuropeptides.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ecdysis-triggering hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables myostimulatory hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hugin
    Names
    CG6371-PA
    Hug-PA
    Hugin-gamma
    Hugin-pyrokinin
    SVPFKPRLamide
    hugin gamma
    pyrokinin
    pyrokinin-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12526188..12529076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079605.2 → NP_524329.1  hugin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VG55
      Related
      FBpp0082108, FBtr0082639
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG55.1 Q9VG55

    Gene LinkOut

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    Other Literature Sources
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