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    mtd mustard [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45467, updated on 27-Dec-2024

    Summary

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    Official Symbol
    mtdprovided by FlyBase
    Official Full Name
    mustardprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013576
    Locus tag
    Dmel_CG32464
    See related
    AllianceGenome:FB:FBgn0013576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey263; CG10196; CG10199; CG32464; Dmel\CG32464; l(3)82Fd; l(3)82FD; L(3)82Fd; L82
    Summary
    Involved in activation of innate immune response; defense response to Gram-negative bacterium; and positive regulation of stem cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; dorsal ectoderm; and embryonic/larval midgut primordium. Used to study cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human NCOA7 (nuclear receptor coactivator 7) and OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mtd in Genome Data Viewer
    Location:
    82F8-82F10; 3-47.5 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5270116..5350443, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1095838..1176165, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45793 Neighboring gene HIF prolyl hydroxylase Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Tim17b1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 82F late puff contains the L82 gene, an essential member of a novel gene family. Stowers RS, et al. Dev Biol, 1999 Sep 1. PMID 10452850
    2. Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction. Wang J, et al. Am J Hum Genet, 2019 Dec 5. PMID 31785787, Free PMC Article
    3. Mutations in the IMD pathway and mustard counter Vibrio cholerae suppression of intestinal stem cell division in Drosophila. Wang Z, et al. mBio, 2013 Jun 18. PMID 23781070, Free PMC Article
    4. Transposon expression in the Drosophila brain is driven by neighboring genes and diversifies the neural transcriptome. Treiber CD, et al. Genome Res, 2020 Nov. PMID 32973040, Free PMC Article
    5. Investigating rare and ultrarare epilepsy syndromes with Drosophila models. Lasko P, et al. Fac Rev, 2021. PMID 33659928, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5343481-5338455 mobile_element_type = transposon:Rt1b{}1218

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mustard
    Names
    CG32464-PA
    CG32464-PAA
    CG32464-PB
    CG32464-PC
    CG32464-PF
    CG32464-PG
    CG32464-PH
    CG32464-PI
    CG32464-PJ
    CG32464-PK
    CG32464-PM
    CG32464-PN
    CG32464-PO
    CG32464-PP
    CG32464-PQ
    CG32464-PR
    CG32464-PS
    CG32464-PT
    CG32464-PU
    CG32464-PV
    CG32464-PW
    CG32464-PX
    CG32464-PY
    l(3)82Fd
    late puff gene at 82F
    mtd-PA
    mtd-PAA
    mtd-PB
    mtd-PC
    mtd-PF
    mtd-PG
    mtd-PH
    mtd-PI
    mtd-PJ
    mtd-PK
    mtd-PM
    mtd-PN
    mtd-PO
    mtd-PP
    mtd-PQ
    mtd-PR
    mtd-PS
    mtd-PT
    mtd-PU
    mtd-PV
    mtd-PW
    mtd-PX
    mtd-PY

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5270116..5350443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143760.4 → NP_652017.1  mustard, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3G4, Q9VNA1, Q9XYU3, Q9XYU4, Q9XYU5, Q9XYU6, Q9XYU7, Q9XYU8
      Related
      FBpp0078453
      Conserved Domains (3) summary
      smart00584
      Location:1108 → 1270
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:271 → 371
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:329 → 371
      LysM; LysM domain

    2. NM_170642.3 → NP_730913.1  mustard, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD53, Q8IPN7
      Related
      FBpp0078457
      Conserved Domains (1) summary
      smart00584
      Location:51 → 213
      TLDc; domain in TBC and LysM domain containing proteins

    3. NM_170644.3 → NP_730915.1  mustard, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730915.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD53, Q7KTR7
      Related
      FBpp0078460
      Conserved Domains (1) summary
      smart00584
      Location:48 → 210
      TLDc; domain in TBC and LysM domain containing proteins

    4. NM_001144534.2 → NP_001138006.1  mustard, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD53, Q8IPN6
      Conserved Domains (1) summary
      smart00584
      Location:30 → 192
      TLDc; domain in TBC and LysM domain containing proteins

    5. NM_001144535.2 → NP_001138007.1  mustard, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138007.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0T6, C8VUZ6
      Conserved Domains (1) summary
      smart00584
      Location:627 → 789
      TLDc; domain in TBC and LysM domain containing proteins

    6. NM_001144536.2 → NP_001138008.1  mustard, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138008.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0T3, C6TPB0
      Conserved Domains (3) summary
      smart00584
      Location:944 → 1106
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:117 → 207
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:165 → 207
      LysM; LysM domain

    7. NM_001144537.2 → NP_001138009.1  mustard, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0T3, C6TPB0
      Conserved Domains (3) summary
      smart00584
      Location:944 → 1106
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:117 → 207
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:165 → 207
      LysM; LysM domain

    8. NM_169047.3 → NP_730918.2  mustard, isoform X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730918.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB0, Q961P8, Q9VNA2
      Conserved Domains (3) summary
      smart00584
      Location:965 → 1127
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:56 → 146
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:104 → 146
      LysM; LysM domain

    9. NM_001260000.2 → NP_001246929.1  mustard, isoform W [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6S8, C6TPB0
      Conserved Domains (3) summary
      smart00584
      Location:1018 → 1180
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:117 → 207
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:165 → 207
      LysM; LysM domain

    10. NM_169038.3 → NP_730909.1  mustard, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3G4, Q9VNA1, Q9XYU3, Q9XYU4, Q9XYU5, Q9XYU6, Q9XYU7, Q9XYU8
      Related
      FBpp0078454
      Conserved Domains (3) summary
      smart00584
      Location:1108 → 1270
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:271 → 371
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:329 → 371
      LysM; LysM domain

    11. NM_001031977.3 → NP_001027148.1  mustard, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3G4, Q9VNA1, Q9XYU3, Q9XYU4, Q9XYU5, Q9XYU6, Q9XYU7, Q9XYU8
      Conserved Domains (3) summary
      smart00584
      Location:1108 → 1270
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:271 → 371
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:329 → 371
      LysM; LysM domain

    12. NM_001260001.2 → NP_001246930.1  mustard, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K699
      Conserved Domains (1) summary
      smart00584
      Location:996 → 1158
      TLDc; domain in TBC and LysM domain containing proteins

    13. NM_169039.5 → NP_730910.2  mustard, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730910.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2F2
      Conserved Domains (3) summary
      smart00584
      Location:1084 → 1246
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:257 → 347
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:305 → 347
      LysM; LysM domain

    14. NM_001043213.3 → NP_001036678.1  mustard, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIB9
      Conserved Domains (3) summary
      smart00584
      Location:1152 → 1314
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:271 → 371
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:329 → 371
      LysM; LysM domain

    15. NM_001259999.2 → NP_001246928.1  mustard, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K620
      Conserved Domains (3) summary
      smart00584
      Location:1182 → 1344
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:271 → 371
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:329 → 371
      LysM; LysM domain

    16. NM_170640.3 → NP_730911.1  mustard, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730911.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB0, Q8IPN9
      Related
      FBpp0078455
      Conserved Domains (3) summary
      smart00584
      Location:893 → 1055
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:26 → 126
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:84 → 126
      LysM; LysM domain

    17. NM_206429.2 → NP_996151.1  mustard, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996151.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB0, Q8IPN5, Q8MSQ5
      Conserved Domains (3) summary
      smart00584
      Location:871 → 1033
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:26 → 126
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:84 → 126
      LysM; LysM domain

    18. NM_001043214.2 → NP_001036679.1  mustard, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB0, Q7KNC5
      Conserved Domains (3) summary
      smart00584
      Location:863 → 1025
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:26 → 126
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:84 → 126
      LysM; LysM domain

    19. NM_001031978.2 → NP_001027149.1  mustard, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB0, Q4ABH3
      Conserved Domains (3) summary
      smart00584
      Location:850 → 1012
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:59 → 113
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:71 → 113
      LysM; LysM domain

    20. NM_001275350.1 → NP_001262279.1  mustard, isoform AA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262279.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF88, C6TPB0
      Conserved Domains (1) summary
      smart00584
      Location:709 → 871
      TLDc; domain in TBC and LysM domain containing proteins

    21. NM_170641.3 → NP_730912.1  mustard, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730912.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB0, Q8IPN8
      Related
      FBpp0078456
      Conserved Domains (1) summary
      smart00584
      Location:707 → 869
      TLDc; domain in TBC and LysM domain containing proteins

    22. NM_170643.3 → NP_730914.1  mustard, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730914.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTR8
      Related
      FBpp0078458
      Conserved Domains (1) summary
      smart00584
      Location:105 → 267
      TLDc; domain in TBC and LysM domain containing proteins

    23. NM_169045.2 → NP_730916.1  mustard, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730916.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD53, Q8IPN6
      Related
      FBpp0078459
      Conserved Domains (1) summary
      smart00584
      Location:30 → 192
      TLDc; domain in TBC and LysM domain containing proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K620 A0A0B4K620
    A0A0B4K699 A0A0B4K699
    A0A0B4K6S8 A0A0B4K6S8
    A0A0B4KF88 A0A0B4KF88
    A4V2F2 A4V2F2
    B7Z0T3 B7Z0T3
    B7Z0T6 B7Z0T6
    Q0KIB9 Q0KIB9
    Q4ABH3 Q4ABH3
    Q7K554 Q7K554
    Q7KNC5 Q7KNC5
    Q7KTR7 Q7KTR7
    Q7KTR8 Q7KTR8
    Q8IPN6 Q8IPN6
    Q8IPN7 Q8IPN7
    Q8IPN8 Q8IPN8
    Q8IPN9 Q8IPN9
    Q8MSQ5 Q8MSQ5
    Q9VNA1 Q9VNA1
    Q9VNA2 Q9VNA2

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